Jessica Green: Are we filtering the wrong microbes?

44,506 views ・ 2011-08-04

TED


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譯者: I-Hsiang Lin 審譯者: Ching-Yuan Chen
00:15
Humans in the developed world
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生活在已開發國家中的人們
00:17
spend more than 90 percent of their lives indoors,
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超過百分之90的時間待在室內,
00:20
where they breathe in and come into contact
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他們呼吸且接觸
00:23
with trillions of life forms invisible to the naked eye:
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肉眼看不見的無數生物:
00:26
microorganisms.
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微生物。
00:28
Buildings are complex ecosystems
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建築物是複雜的生態系統,
00:30
that are an important source
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也是人們取得微生物的重要來源,
00:32
of microbes that are good for us,
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不論是好的,
00:34
and some that are bad for us.
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還是不好的微生物。
00:36
What determines the types and distributions
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什麼因素決定了室內微生物的
00:39
of microbes indoors?
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種類和分布?
00:41
Buildings are colonized by airborne microbes
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佔據在建築物內的空氣傳播微生物
00:44
that enter through windows
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經由窗戶
00:46
and through mechanical ventilation systems.
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和機械通風裝置進入室內。
00:49
And they are brought inside
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也經由人類和其它生物
00:51
by humans and other creatures.
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帶入室內。
00:54
The fate of microbes indoors
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室內微生物的命運
00:56
depends on complex interactions
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取決於
00:58
with humans,
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其與人類的互動
01:00
and with the human-built environment.
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和與人造環境的互動
01:02
And today, architects and biologists
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現今,建築師和生物學家
01:04
are working together
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一起合作
01:06
to explore smart building design
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探索聰慧的建築設計
01:09
that will create
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以創造
01:11
healthy buildings for us.
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對人們健康的建築物。
01:14
We spend an extraordinary amount of time
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我們花非常大量的時間
01:16
in buildings
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待在建築物內,
01:18
that are extremely controlled environments,
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建築物是被高度控制的環境,
01:21
like this building here --
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像這座建築物--
01:23
environments that have mechanical ventilation systems
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裝設有機械通風系統
01:26
that include filtering,
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包括過濾,
01:28
heating and air conditioning.
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暖氣和空氣調節設備。
01:30
Given the amount of time that we spend indoors,
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考量到我們待在室內的時間,
01:32
it's important to understand
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了解這如何影響我們的健康
01:34
how this affects our health.
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是很重要的事。
01:36
At the Biology and the Built Environment Center,
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在這座生物和人造環境中心裡,
01:39
we carried out a study in a hospital
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我們進行一項醫院內的研究,
01:42
where we sampled air
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我們取樣醫院裡的空氣,
01:44
and pulled the DNA
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從空氣中的微生物
01:46
out of microbes in the air.
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擷取DNA。
01:48
And we looked at three different types of rooms.
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我們著眼於三種不同類型的房間。
01:51
We looked at rooms that were mechanically ventilated,
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有機械通風設備的房間
01:53
which are the data points in the blue.
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是圖表中的藍數據點。
01:55
We looked at rooms that were naturally ventilated,
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我們研究自然通風的地方
01:58
where the hospital let us turn off the mechanical ventilation
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是醫院允許我們關閉機械通風設備的房間
02:00
in a wing of the building
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它們位於醫院的側翼
02:02
and pry open the windows
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我們翹開的窗戶
02:04
that were no longer operable,
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實際上早已不能使用,
02:06
but they made them operable for our study.
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為了我們的研究,醫院恢復它們的功能。
02:08
And we also sampled the outdoor air.
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我們也從戶外空氣中取樣。
02:10
If you look at the x-axis of this graph,
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如果你看此表的X軸,
02:13
you'll see that what we commonly want to do --
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可觀察到我們普通的作法--
02:16
which is keeping the outdoors out --
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把戶外空氣排除在外--
02:18
we accomplished that with mechanical ventilation.
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我們藉由機械通風達成此目的。
02:21
So if you look at the green data points,
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如果你看表中的綠數據點,
02:23
which is air that's outside,
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這是戶外的空氣,
02:25
you'll see that there's a large amount of microbial diversity,
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你可看到有大量的微生物多樣性,
02:28
or variety of microbial types.
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或者多樣化的微生物種類。
02:30
But if you look at the blue data points,
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但如果你看藍數據點,
02:32
which is mechanically ventilated air,
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它們代表機械通風的空氣,
02:34
it's not as diverse.
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種類沒那麼多樣化。
02:37
But being less diverse
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但是種類少
02:39
is not necessarily good for our health.
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不一定對我們的健康有益處。
02:41
If you look at the y-axis of this graph,
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如果你看表中的Y軸,
02:44
you'll see that, in the mechanically ventilated air,
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你可看到,機械通風的空氣中,
02:47
you have a higher probability
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你有較高的可能性
02:49
of encountering a potential pathogen,
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會接觸到潛在的病原體,
02:51
or germ,
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或病菌,
02:53
than if you're outdoors.
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在戶外時,可能性反而較小
02:55
So to understand why this was the case,
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為了瞭解其背後的原因,
02:58
we took our data
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我們把這些資料
03:00
and put it into an ordination diagram,
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排列在序列分布圖中,
03:02
which is a statistical map
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形成一個統計地圖,
03:04
that tells you something
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這個圖可告訴你
03:06
about how related the microbial communities are
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在不同的樣本中
03:08
in the different samples.
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微生物族群的關聯性。
03:10
The data points that are closer together
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位置相近的點
03:12
have microbial communities that are more similar
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帶有較類似的微生物族群,
03:15
than data points that are far apart.
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位置距離較遠的點則反之
03:17
And the first things that you can see from this graph
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可從此圖表中發現的第一件事是
03:19
is, if you look at the blue data points,
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如果你看這些藍數據點
03:21
which are the mechanically ventilated air,
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它們代表機械通風的空氣,
03:24
they're not simply a subset of the green data points,
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他們不單純只是綠數據點的子集,
03:27
which are the outdoor air.
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綠數據點代表戶外空氣。
03:29
What we've found is that mechanically ventilated air
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我們所發現的是機械通風的空氣
03:32
looks like humans.
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看似人類的。
03:34
It has microbes on it
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漂浮其中的微生物
03:36
that are commonly associated with our skin
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和我們的皮膚、嘴巴和唾液
03:39
and with our mouth, our spit.
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有共通關連性。
03:41
And this is because
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這是因為
03:43
we're all constantly shedding microbes.
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我們全部的人不斷地散播微生物。
03:45
So all of you right now
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現在你們全部的人
03:47
are sharing your microbes with one another.
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正在彼此分享彼此的微生物。
03:49
And when you're outdoors,
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當你們在戶外時,
03:51
that type of air has microbes
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空氣中所帶的微生物
03:53
that are commonly associated with plant leaves and with dirt.
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和植物葉子還有土攘有關連性。
03:56
Why does this matter?
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這為什麼重要呢?
03:58
It matters because the health care industry
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其重要性在於醫療保健產業
04:00
is the second most energy intensive industry
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排名美國第二大
04:03
in the United States.
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高耗能產業。
04:05
Hospitals use two and a half times
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醫院所耗能源
04:07
the amount of energy as office buildings.
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是辦公建築物的2.5倍。
04:10
And the model that we're working with
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現今醫院奉行的
04:12
in hospitals,
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典範,
04:14
and also with many, many different buildings,
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同時也可見於很多不同建築之中,
04:16
is to keep the outdoors out.
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是將戶外空氣排除在外。
04:18
And this model
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而這個典範
04:20
may not necessarily be the best for our health.
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不一定是對我們健康最有益處的。
04:23
And given the extraordinary amount
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鑒於非常大量的
04:25
of nosocomial infections,
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醫院感染,
04:27
or hospital-acquired infections,
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或者經由醫院取得的感染,
04:30
this is a clue that it's a good time
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這提醒我們,是時候
04:32
to reconsider our current practices.
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重新考慮目前的常規是否合適。
04:35
So just as we manage national parks,
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如同我們管理國家公園,
04:38
where we promote the growth of some species
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當我們促進一些物種的成長時,
04:40
and we inhibit the growth of others,
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我們也抑制其它物種的成長,
04:43
we're working towards thinking about buildings
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我們正把生態系統的架構
04:46
using an ecosystem framework
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應用到建築的思維裡,
04:48
where we can promote the kinds of microbes
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提升我們想要移到室內的
04:51
that we want to have indoors.
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某些微生物種類。
04:55
I've heard somebody say
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我聽過人說
04:57
that you're as healthy as your gut.
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你的健康取決於你的腸道健康。
04:59
And for this reason, many people eat probiotic yogurt
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因此很多人吃益生菌優格
05:02
so they can promote a healthy gut flora.
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就是為了促進健康的腸道菌叢。
05:05
And what we ultimately want to do
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我們的終極目標
05:07
is to be able to use this concept
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是應用此概念
05:10
to promote a healthy group
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促進室內的
05:12
of microorganisms inside.
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健康微生物群。
05:14
Thank you.
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謝謝。
05:16
(Applause)
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(掌聲)
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