Tal Golesworthy: How I repaired my own heart

Translator: Irma Sutlic Reviewer: Tilen Pigac - EFZG

Sem procesni inženir.

I'm a process engineer, I know all about boilers and incinerators

Vem vse o bojlerjih in sežigalnikih

and fabric filters, and cyclones, and things like that.

in tekstilnih filtrih in ciklonskih motorjih in podobnem,

imam pa tudi Marfanov sindrom.

But I also have Marfan syndrome.

To je prirojena napaka.

This is an inherited disorder.

And in 1992, I participated in a genetic study,

In leta 1992

sem sodeloval v genetski raziskavi

and found to my horror, as you can see from the slide,

ter se zgrozil ob spoznanju, kot lahko razberete z grafa,

that my ascending aorta was not in the normal range,

da moja ascendentna aorta ni v normalnem razponu,

kot označuje zeleni pas spodaj.

the green line at the bottom.

Vsi znotraj tega pasu so med 3,2 in 3,6 cm.

Everyone in here will be between 3.2-3.6,

Jaz pa sem bil že na 4,4 cm.

and I was already up at 4.4.

And as you can see, my aorta dilated progressively,

Kot lahko razberete,

se je moja aorta vedno bolj razširjala,

and I got closer and closer to the point where surgery was going to be necessary.

in bližal sem se točki,

ko je bila potrebna operacija.

The surgery on offer was pretty gruesome.

Ponujena operacija je bila precej grozljiva --

anestezija, odprejo ti prsni koš,

Anesthetize you, open your chest,

put you on an artificial heart and lung machine,

te priključijo na umetno srce in pljuča,

drop your body temperature to about 18 centigrade,

znižajo telesno temperaturo na okrog 18 stopinj,

stop your heart, cut the aorta out,

ustavijo ti srce, izrežejo aorto,

replace it with a plastic valve and a plastic aorta.

jo zamenjajo s plastično zaklopko in plastično aorto,

in, najbolj pomembno,

And most importantly, commit you to a lifetime of anticoagulation therapy.

te obsodijo na doživljenjsko terapjo z antikoagulanti,

običajno je to warfarin.

Normally, warfarin.

Misel na operacijo ni bila privlačna.

The thought of the surgery was not attractive.

The thought of the warfarin was really quite frightening.

Misel na warfarin

je bila v resnici prav strašljiva.

Tako sem si rekel, inženir sem, delam v raziskavah in razvoju,

So I said to myself,

"I'm an engineer, I'm in R&D, this is just a plumbing problem."

tole je le vodovodarski problem.

To zmorem. To lahko spremenim.

"I can do this, I can change this."

Tako sem si zastavil,

So I set out to change the entire treatment for aortic dilation.

da spremenim celotno zdravljenje

aortne razširitve.

The project aim is really quite simple.

Cilj projekta je prav preprost.

The only real problem with the ascending aorta

Edini resnični problem z ascendentno aorto

in people with Marfan syndrome

pri ljudeh z Marfanovim sindromom je,

is that it lacks some tensile strength.

da ji manjka natezne trdnosti.

Torej obstaja možnost,

So, the possibility exists to simply externally wrap the pipe,

da bi preprosto od zunaj ovili cev.

and it would remain stable and operate quite happily.

In bi ostala stabilna in delovala prav srečno.

Če vaša visokotlačna cev

If your high-pressure hose pipe or hydraulic line bulges a little,

ali vaša visokotlačna linija dobi izboklino,

preprosto navijete nekaj traku okoli nje z zunanje strani.

you just wrap some tape around it, it really is that simple.

V zasnovi je to tako preprosto,

In concept, though not in execution.

ni pa tako v izvedbi.

The great advantage of an external support, for me,

Zame je bila velika prednost zunanje opore v tem,

was that I could retain all of my own bits,

da bi lahko obdržal vse svoje delčke,

all of my own endothelium and valves,

ves svoj endotelij in vse zaklopke,

and not need any anticoagulation therapy.

in da ne bi potreboval terapije s sredstvi proti strjevanju krvi.

Kje torej začeti?

So, where do we start?

Tole je prerez mene skozi sredinsko ravnino.

This is a sagittal slice through me.

Na sredini lahko vidite

In the middle, you can see that little structure squeezing out,

tisto napravico, majhno strukturo, kako izstiska.

that's the left ventricle,

To je levi srčni prekat,

pushing blood out through the aortic valve.

ki potiska kri navzgor skozi aortno zaklopko --

tamle lahko vidite, kako delujeta lističa aortne zaklopke --

You can see two of the leaflets of the aortic valve working there.

Up into the ascending aorta.

navzgor v ascendentno aorto.

And it's that part, the ascending aorta,

In to je ta del, ascendentna aorta,

ki se razširja in končno poči,

which dilates and ultimately bursts, which of course is fatal.

kar je, seveda, smrtno.

We started by organizing image acquisition

Začeli smo tako, da smo organizirali zajemanje slik

from magnetic resonance and CT imaging machines,

z naprav za magnetno resonančno slikanje

in z naprav za CT slikanje,

from which to make a model of the patient's aorta.

da bi iz njih naredili model

bolnikove aorte.

Tole je model moje aorte.

This is a model of my aorta.

I've got a real one in my pocket,

V žepu imam resnični model,

if anyone would like to look at it, and play with it.

če bi ga kdo rad pogledal in se z njim poigral.

(Laughter)

You can see it's quite a complex structure.

Kot vidite, je precej kompleksna struktura.

It has a funny tri-lobal shape at the bottom,

Pri dnu ima hecno tristrano obliko,

which contains the aortic valve.

ki vsebuje aortno zaklopko.

It then comes back into a round form,

Potem preide nazaj v okroglo obliko,

and then tapers and curves off.

se zoži in se ukrivi dalje.

Precej zapletena struktura,

It's quite a difficult structure to produce.

če jo hočeš izdelati.

To je, kot sem dejal, moj CAD model,

This is a sort of CAD model of me,

and this is one of the later CAD models.

in to je eden kasnejših CAD modelov.

We went through an iterative process of producing better and better models.

Šli smo skozi iterativni postopek

izdelovanja boljših in boljših modelov.

Ko smo izdelali ta model,

When we produced that model,

we turned it into a solid, plastic model, as you can see,

smo ga spremenili v otipljiv plastični model,

kot vidite,

using a rapid prototyping technique, another engineering technique.

in sicer z uporabo tehnike za hitro izdelavo prototipov,

kar je še ena izmed inženirskih tehnik.

We then used that former

Ta model kot kalup uporabimo za to,

to manufacture a perfectly bespoke porous textile mesh,

da popolnoma po meri izdelamo

porozno tekstilno mrežo,

which takes the shape of the former and perfectly fits the aorta.

ki posnema obliko kalupa

in se popolnoma prilega aorti.

So this is absolutely personalized medicine at its best, really.

Tole je torej absolutno personalizirana medicina

v svoji resnično najboljši izvedbi.

Vsak bolnik, ki ga obravnavamo,

Every patient we do has an absolutely bespoke implant.

ima absolutno po meri izdelan vsadek.

Once you've made it, the installation is quite easy.

Ko je enkrat izdelan, je namestitev preprosta.

John Pepper, bless his heart, professor of cardiothoracic surgery.

John Pepper, blagoslovljeno bodi njegovo srce,

profesor kardiotorakalne kirurgije --

še nikoli prej ni tega naredil --

Never done it before in his life, he put the first one in, didn't like it,

je vstavil prvega, nekaj mu ni bilo všeč in ga je vzel ven,

he put the second one in.

in potem vstavil drugega. Odšel sem, srečen.

Happy, away I went.

Štiri in pol ure na mizi, in je bilo narejeno vse.

Four and a half hours on the table, and everything was done.

Kirurška implantacija je bila dejansko lažji del vsega.

So the surgical implantation was actually the easiest part.

Če našo obravnavo primerjate z obstoječo alternativo,

If you compare our new treatment to the existing alternative,

ki je zamenjava aortnega korena z vsadkom iz kompozitnega materiala,

the composite aortic root graft,

there are one or two startling comparisons

najdete osupljivo razliko ali dve,

which I'm sure will be clear to all of you.

za katere verjamem, da vam bodo vsem jasne.

Two hours to install one of our devices,

Dve uri za vsaditev ene izmed naših naprav

v primerjavi s šestimi urami

compared to 6 hours for the existing treatment.

pri obstoječi obravnavi.

Obstoječa obravnava, kot sem že povedal,

As I said, the existing treatment requires the heart-lung bypass machine,

zahteva napravo za obvod srca in pljuč

and it requires a total body cooling.

in zahteva znižanje telesne temperature.

We don't need any of that. We work on a beating heart.

Ne potrebujemo ničesar od tega; delamo na utripajočem srcu.

He opens you up,

Kirurg te odpre, doseže aorto medtem ko srce utripa,

he accesses the aorta while your heart is beating,

vse pri pravi temperaturi.

all at the right temperature.

No breaking into your circulatory system.

Nobenega vdora v krvni sistem.

So it really is great.

Torej je res enkratno.

But for me, absolutely the best point is,

Vendar je zame absolutno najboljše dejstvo to,

there is no anticoagulation therapy required.

da ni treba nobene terapije z antikoagulanti.

I don't take any drugs at all,

Ne jemljem nobenih substanc za zdravljenje,

other than recreational ones that I would choose to take.

razen kakšnih substanc, ki bi jih hotel jemati zaradi užitka.

(Smeh)

(Laughter)

And in fact, if you speak to people who are on long-term warfarin,

Dejansko vidite, če govorite z ljudmi, ki dolgoročno jemljejo warfarin,

it is a serious compromise to your quality of life,

da je to resna ovira za kvaliteto življenja.

and even worse, it inevitably foreshortens your life.

Celo huje,

neizogibno skrajšuje življenje.

In še, če imate opcijo z umetno zaklopko,

Likewise, if you have the artificial valve option,

you're committed to antibiotic therapy

ste obsojeni na terapijo z antibiotiki

whenever you have any intrusive medical treatment,

kadarkoli imate kakšen intruzivni medicinski poseg.

even trips to the dentist require that you take antibiotics,

Celo obiski pri zobozdravniku zahtevajo, da jemljete antibiotike,

in case you get an internal infection on the valve.

če bi morda dobili notranje okužbe zaklopke.

Again, I don't have any of that, so I'm entirely free,

Torej, ničesar od tega nimam, čisto svoboden sem.

my artery is fixed.

Moja aorta je popravljena, ni mi treba biti zaskrbljen zaradi nje,

I haven't got to worry about it, which is a rebirth for me.

zame je to preporod.

Nazaj k temi moje predstavitve:

Back to the theme of the presentation, multidisciplinary research,

multidisciplinarne raziskave.

how on earth does a process engineer used to working with boilers

Kako neki procesni inženir, ki je vajen delati z bojlerji,

end up producing a medical device which transforms his own life?

na koncu naredi medicinsko napravo,

ki spremeni njegovo lastno življenje?

Well, the answer to that is, a multidisciplinary team.

No, odgovor na to je multidisciplinarni tim strokovnjakov.

This is a list of the core team,

Tole je seznam nosilceva tima.

and you can see there aren't only two principal technical disciplines there,

Kot lahko vidite,

ne gre za zgolj dve poglavitni tehnični področji,

medicine and engineering,

za medicino in strojništvo,

but also, there are various specialists from within those two disciplines.

ampak gre tudi za različne specialiste

znotraj teh dveh področij.

John Pepper was the cardiac surgeon who did all the actual work on me.

John Pepper, tamle,

je bil srčni kirurg, ki je dejansko opravil delo na meni,

But everyone else had to contribute one way or another.

vendar so tudi vsi ostali našteti tamle morali tako ali drugače prispevati.

Raad Mohiaddin, a medical radiologist.

Raad Mohiaddin, je na primer medicinski radiolog:

We had to get good-quality images from which to make the CAD model.

morali smo priti do slik dobre kvalitete,

da bi lahko iz njih izdelali model CAD.

Warren Thornton, who still does all our CAD models for us,

Warren Thornton, ki še sedaj za nas pripravlja vse modele CAD,

had to write a bespoke piece of CAD code

je moral po meri napisati kodo za model CAD,

to produce this model from this really rather difficult input data set.

da bi lahko izdelali ta model

iz resnično precej zahtevnih vhodnih podatkov.

There are some barriers to this, though, there are some problems.

Kar nekaj preprek je v zvezi z vsem tem. Kar nekaj problemov,

strokovni žargon že je precejšnji.

Jargon is a big one.

I would think no one in this room understands the first four jargon points.

Najbrž nihče v tem prostoru ne razume

prvih štirih točk iz žargona tamle.

The engineers amongst you will recognize "rapid prototyping" and "CAD."

Tisti, ki ste inženirji,

boste prepoznali izraza hitra izdelava prototipov in CAD.

The medics amongst you, if there are any, will recognize the first two,

Tisti med vami, ki ste s področja zdravstva, če vas je kaj, boste prepoznali prva dva.

but there will be nobody else here that understands all those four words.

Ampak v tem prostoru ne bomo našli nikogar,

ki bi razumel vse štiri izraze.

Taking the jargon out was very important

Zelo pomembno je bilo odstraniti žargon,

to ensure that everyone in the team understood exactly what was meant

če smo hoteli zagotoviti, da bo vsak član skupine

natanko razumel, kaj je bilo mišljeno,

when a particular phrase was used.

ko je bil uporabljen določen izraz.

Različna strokovna področja imajo različne dogovore, kar je bil prav tako hec.

Our disciplinary conventions were funny as well.

We took a lot of horizontal slice images through me,

Posneli smo veliko slik, ki so prikazovale vodoravne prereze skozi mene,

produced those slices and used them to build a CAD model.

te prereze potem sestavili in iz tega potem zgradili model CAD.

And the very first CAD model we made,

Čisto prvi zgrajeni model,

the surgeons were playing with it and couldn't quite figure it out.

iz plastike, so kirurgi obračali v rokah,

pa niso mogli ugotoviti, kaj bi to bilo.

And then we realized that it was actually a mirror image of the real aorta.

Nakar smo ugotovili, da je bil model zrcalna podoba

dejanske aorte.

And it was a mirror image because in the real world,

Zrcalna podoba pa je bil zato,

ker v resničnem svetu načrte gledamo vedno navzdol,

we always look down on plans,

plans of houses, or streets, or maps.

na primer načrte hiš, ulic ali zemljevide.

In the medical world, they look up at plans.

V svetu medicine načrte gledajo navzgor.

So the horizontal images were all in inversion.

In zato so bili posnetki vodoravnih prerezov vsi inverzni.

So, one needs to be careful with disciplinary conventions.

Torej je treba paziti na to, kakšne dogovore imajo različna strokovna področja.

Everyone needs to understand what is assumed and what is not.

Vsak mora razumeti,

kaj je privzeto, kaj pa ne.

Pregrade med različnimi ustanovami

Institutional barriers were another serious headache in the project.

so povzročale še eno vrsto resnih glavobolov v projektu.

The Brompton Hospital was taken over

Bolnišnico Brompton je prevzela

by the Imperial College School of Medicine.

medicinska šola ustanove Imperial College,

And there are some seriously bad relationship problems

in bilo je nekaj hudih problemov v odnosih

med tema organizacijama.

between the two organizations.

I was working with the Imperial and the Brompton,

Delal sem tako z ustanovo Imperial kot z bolnišnico Brompton,

kar pa je bilo izvor resnih težav v projektu,

and this generated some serious problems for the project.

Really, problems that shouldn't exist.

težav, ki jih v resnici ne bi smelo biti.

Research & Ethics Committee.

Komisija za raziskave in etiko: Če hočete v kirurgijo vpeljati nekaj novega,

If you want to do anything new in surgery,

potrebujete dovoljenje od svoje lokalne komisije.

you have to get a license from your local Research & Ethics.

Prepričan sem, da enako velja tudi na Poljskem.

I'm sure it's the same in Poland.

Gotovo imajo nekaj podobnega,

There will be some form of equivalent which licenses new types of surgery.

kar odobri nove načine kirurških posegov.

We didn't only have the bureaucratic problems associated with that,

Ne samo, da smo v zvezi s tem imeli birokratske probleme,

we also had professional jealousies.

opraviti smo imeli tudi z zavistjo med strokovnjaki.

There were people on the Research & Ethics committee

V komisiji za raziskave in etiko so bile osebe,

ki resnično niso želele videti, kako je John Pepper ponovno uspešen,

who really didn't want to see John Pepper succeed again.

saj je tako zelo uspešen.

Because he is so successful.

And they made extra problems for us.

In so nam posebej delali probleme.

Bureaucratic problems.

Birokratski problemi:

Ultimately, when you have a new treatment,

Ko končno imaš nov način zdravljenja,

you have to have a guidance note for all the hospitals in the country.

moraš imeti objavljeno obvestilo z navodili,

ki ga prejmejo vse bolnišnice v državi.

In the UK, we have the National Institute and Clinical Excellence.

V Veliki Britaniji imamo v ta namen ustanovo National Institute for Clinical Excellence, kratko NICE.

Brez dvoma najdete nekaj podobnega na Poljskem.

You have an equivalent in Poland, no doubt.

Morali smo preseči neprijetni problem z NICE.

And we had to get past the NICE problem.

Sedaj imamo na spletu krasna klinična navodila.

We now have a great clinical guidance, out on the net.

In tako lahko pristopijo vse zainteresirane bolnišnice,

So any other hospitals interested can come along, read the NICE report,

preberejo poročilo NICE,

get in touch with us, and then get doing it themselves.

stopijo v stik z nami, in začnejo to izvajati tudi sami.

Prepreke s financiranjem:

Funding barriers, another big area to be concerned with.

Še eno veliko področje, za katero je treba poskrbeti.

Imeli smo velik problem z razumevanjem enega od naslednjih stališč:

A big problem with understanding one of those perspectives.

ko smo prvič zaprosili

When we first approached one of the big, charitable UK organizations

pri eni od velikih britanskih dobrodelnih organizacij, ki financira take reči,

that fund this kind of stuff,

so oni pravzaprav videli prošnjo s področja tehnike.

we essentially gave them an engineering proposal.

They didn't understand it, they were doctors, next to God,

Enostavno niso razumeli; bili so zdravniki, bili so skoraj bogovi.

Gotovo je zanič. Vrgli so v smeti.

it must be rubbish, they binned it.

Na koncu sem šel do zasebnih vlagateljev,

So in the end, I went after private investors, just gave up on it.

glede tistega pa vrgel puško v koruzo.

Most R&D is going to be institutionally funded,

Ampak večino raziskav in razvoja financirajo ustanove,

by the Polish Academy of Sciences

na primer Poljska akademija znanosti

ali Raziskovalni svet za tehnične in fizikalne znanosti ali karkoli že,

or the Engineering and Physical Sciences Research Council, or whatever.

And you need to get past those people.

in treba je priti okrog teh ljudi.

Žargon je hud problem, ko poskušaš delovno povezati različna področja.

Jargon is a huge problem when you try to work across disciplines,

Razlog je v tem, da na primer v tehniškem svetu

because in an engineering world, we all understand CAD and RP.

vsi razumemo CAD in R.P. --

Not in the medical world.

ne pa v svetu medicine.

Najbrž morajo birokrati za financiranje nekoč le spraviti skupaj svoj dokument.

I suppose the funding bureaucrats ultimately have to get their act together.

Zares se morajo začeti pogovarjati med sabo

They've really got to start talking to each other,

in morajo pokazati kanček domišljije,

and exercise a bit of imagination, if that's not too much to ask.

če jih s tem ne prosimo preveč --

(Laughter)

Which it probably is.

no najbrž jih.

(Laughter)

I've coined the phrase "obstructive conservatism."

Skoval sem izraz "obstruktivni konzervativizem".

So many people in the medical world don't want to change.

Mnogi ljudje v medicini se namreč ne želijo spremeniti,

Particularly when some jumped-up engineer has come along with the answer.

še posebej ne, kadar z odgovorom pride mimo kakšen povzpetni inženir.

Nočejo se spremeniti.

They don't want to change.

They simply want to do whatever they've done before.

Preprosto hočejo početi to, kar so počeli do tedaj.

Dejansko je še zdaj v Veliki Britaniji veliko kirurgov,

And in fact, many surgeons in the UK are still waiting

ki še čakajo, da bi kateri od naših bolnikov

for one of our patients to have some sort of an episode,

imel kakšen zaplet,

so that they could say, "Told you that was no good."

da bi lahko rekli, "Aha, sem rekel, da to ne bo dobro."

We've actually got 30 patients.

Dejansko smo imeli 30 bolnikov.

At seven and a half years,

Pri meni je minilo sedem let in pol.

we've got 90 post-op patient years between us,

Skupaj naberemo bolniki 90 let od operacije,

and we haven't had a single problem.

pa nismo imeli niti enega problema.

And still, there are people in the UK saying,

Pa še vedno v Veliki Britaniji obstajajo ljudje, ki rečejo,

"That external aortic root, it will never work, you know."

"Ja, tale aortni koren z zunanjo oporo, to ne bo nikdar delovalo, veste."

It really is a problem.

Resnično je to problem. Resnično je to problem.

Zagotovo se je že vsak v tem prostoru kdaj srečal z aroganco

I'm sure everyone in this room has come across arrogance

zdravstvenih delavcev, zdravnikov ali kirurgov.

amongst medics, doctors, surgeons, at some point.

The middle point is simply the way that the doctors protect themselves.

Posredi je preprosto način,

kako se zdravniki zaščitijo.

"Well, of course, I'm looking after my patient."

"Ja, seveda, pazim na svojega bolnika."

I think it's not good, but that's my view.

Mislim, da ni dobro tako, ampak poglejte, to je moje stališče.

Egos, of course, again a huge problem.

Ego je seveda spet velikanski problem.

Če delate v multidisciplinarni skupini,

If you work in a multidisciplinary team,

je treba člane jemati malo z rezervo.

you've got to give your guys the benefit of the doubt,

you've got to express support for them.

Treba jim je izražati podporo.

Tom Treasure, professor of cardiothoracic surgery.

Tom Treasure, profesor kardiotorakalne kirurgije na primer

je neverjeten človek.

Incredible guy.

Dead easy to give him respect.

Prav lahko ga je spoštovati.

Him giving me respect? Slightly different.

Da bi on spoštoval mene? Malo drugačna zgodba.

(Laughter)

To je vse, kar se tiče slabih novic.

That's all the bad news.

The good news is, the benefits are stonkingly huge.

Dobra novica je, da so prednosti groziljansko velike.

Translate that one! I bet they can't.

No, pa naj prevedejo to. Stavim, da ne znajo.

(Smeh)

(Laughter)

When you have a group of people with different professional training,

Ko so na kupu ljudje,

ki so imeli različno strokovno šolanje in različne strokovne izkušnje,

a different professional experience,

they not only have a different knowledge base,

nimajo le različnih temeljnih znanj,

ampak imajo različne poglede na vse.

but also a different perspective on everything.

In če jih lahko spravite

And if you can bring them together,

skupaj in jih pripravite do tega, da med sabo govorijo in se razumejo,

and get them talking and understanding each other,

the results can be spectacular.

so rezultati lahko spektakularni.

You can find really novel solutions that have never been looked at before,

Lahko odkrijete nove rešitve, resnično nove rešitve,

ki jih še nihče ni oplazil s pogledom,

very quickly and easily.

in to hitro in lahko.

You can short-cut huge amounts of work

Lahko skrajšate velikanske količine dela s tem,

simply by using the extended knowledge base you have.

da preprosto uporabite razširjeno bazo znanja, ki je pri roki.

In kot rezultat

And as a result, it's an entirely different use

dobite popolnoma drugačno uporabo tehnologije

in znanja okrog vas.

of the technology and the knowledge around you.

Rezultat vsega tega je,

The result of all this is that you can get incredibly quick progress

da lahko dobite neverjetno hiter napredek

on incredibly small budgets.

z neverjetno majhnim proračunom.

I'm so embarrassed at how cheap it was to get from my idea

Tako nerodno mi je zaradi tega, kako poceni je bilo

priti od moje ideje do tega, da sem dobil vsadek,

to me being implanted

da vam sploh nisem pripravljen povedati, koliko je stalo.

that I'm not prepared to tell you what it cost,

Zato ker sumim,

because I suspect there are absolutely standard surgical treatments,

da obstajajo čisto standardna kirurška zdravljenja,

najbrž v ZDA,

probably in the USA,

which cost more for a one-off patient

ki stanejo več

za povsem serijsko zdravljenje posameznega bolnika

than the cost of us getting from my dream to my reality.

kot pa je stalo nas, da pridemo od mojih sanj

do moje resničnosti.

That's all I want to say, and I've got three minutes left.

To je vse, kar sem hotel povedati, in tri minute so mi še ostale.

So, Ewa's going to like me.

To pomeni, da bom najbrž všeč Heather.

If you have any questions, please come up and talk to me later on,

Če imate še kakšna vprašanja, stopite do mene kasneje in me vprašajte.

it would be a pleasure to speak with you.

V veselje mi bo govoriti z vami. Hvala lepa.

Many thanks.

(Applause)