Award-winning teen-age science in action

83,731 views ・ 2012-01-10

TED


请双击下面的英文字幕来播放视频。

翻译人员: Xu Jiang 校对人员: Guo Tang
00:15
Lauren Hodge: If you were going to a restaurant and wanted a healthier option,
0
15260
3000
劳伦·霍奇:如果你去饭店,你想吃得健康一点,
00:18
which would you choose, grilled or fried chicken?
1
18260
2000
你会选择哪种食品呢,烤鸡还是炸鸡?
00:20
Now most people would answer grilled,
2
20260
2000
多数人都会选择烤鸡,
00:22
and it's true that grilled chicken does contain less fat and fewer calories.
3
22260
3000
的确,烤鸡含有较少的脂肪和卡路里。
00:25
However, grilled chicken poses a hidden danger.
4
25260
2000
但是,烤鸡存在一个潜在的危险
00:27
The hidden danger is heterocyclic amines --
5
27260
2000
这个潜在的危险是多环胺类--
00:29
specifically phenomethylimidazopyridine,
6
29260
2000
具体的来讲,是phenomethylimidazopyridine,
00:31
or PhIP --
7
31260
2000
或者简称为PhIP--
00:33
(laughter)
8
33260
2000
(笑声)
00:35
which is the immunogenic or carcinogenic compound.
9
35260
3000
是免疫原性或致癌物质的成分
00:38
A carcinogen is any substance or agent
10
38260
2000
致癌物质是任何
00:40
that causes abnormal growth of cells,
11
40260
2000
会导致细胞的异常增长,
00:42
which can also cause them to metastasize or spread.
12
42260
3000
也会导致细胞的转移和扩张的介质
00:45
They are also organic compounds
13
45260
2000
它们也是有机物
00:47
in which one or more of the hydrogens in ammonia
14
47260
3000
氨中的一个或多个氢
00:50
is replaced with a more complex group.
15
50260
2000
被替换成更复杂的组成
00:52
Studies show that antioxidants
16
52260
2000
研究显示抗氧化剂
00:54
are known to decrease these heterocyclic amines.
17
54260
2000
能减少这些杂胺环
00:56
However, no studies exist yet
18
56260
2000
但是,现在还没有研究
00:58
that show how or why.
19
58260
2000
显示通过如何方式或者为什么
01:00
These here are five different organizations that classify carcinogens.
20
60260
3000
这是五个不同的组织对致癌物的分类
01:03
And as you can see, none of the organizations consider the compounds to be safe,
21
63260
3000
如同你所看到的,没有任何一个组织认为该组成物是安全的,
01:06
which justifies the need to decrease them in our diet.
22
66260
3000
就是说我们需要在饮食中减少对它们的摄入
01:09
Now you might wonder how a 13 year-old girl could come up with this idea.
23
69260
3000
现在你可能会问一个13岁的女孩怎么会想到这一点
01:12
And I was led to it through a series of events.
24
72260
2000
是一系列的事件将我引导至此的。
01:14
I first learned about it through a lawsuit I read about in my doctor's office --
25
74260
3000
首先,是我在医生那里听到的一个诉讼案
01:17
(Laughter)
26
77260
3000
(笑声)
01:20
which was between the Physician's Committee for Responsible Medicine
27
80260
3000
是关于责任医学委员会
01:23
and seven different fast food restaurants.
28
83260
2000
和七个不同的快餐店之间的诉讼
01:25
They weren't sued because there was carcinogens in the chicken,
29
85260
3000
快餐店被告并不是因为在鸡肉中有致癌物质,
01:28
but they were sued because of California's Proposition 65,
30
88260
4000
而是因为加利福尼亚州65号提案,
01:32
which stated that if there's anything dangerous in the products
31
92260
3000
提案要求如果产品中有任何有害成分
01:35
then the companies had to give a clear warning.
32
95260
2000
公司应该给出明确的警告
01:37
So I was very surprised about this.
33
97260
2000
我对此很惊讶
01:39
And I was wondering why nobody knew more
34
99260
2000
我很奇怪为什么没有人知道
01:41
about this dangerous grilled chicken,
35
101260
2000
有害烤鸡,
01:43
which doesn't seem very harmful.
36
103260
2000
虽然它们看起来不那么有害
01:45
But then one night, my mom was cooking grilled chicken for dinner,
37
105260
3000
但是一天晚上,晚餐时我妈妈在烤鸡,
01:48
and I noticed that the edges of the chicken,
38
108260
2000
我注意到鸡肉的边缘,
01:50
which had been marinated in lemon juice, turned white.
39
110260
3000
经过柠檬汁的浸泡,变白了。
01:53
And later in biology class, I learned that it's due to a process called denaturing,
40
113260
3000
后来在生物课上,我学到这是由于一种叫变性的过程,
01:56
which is where the proteins will change shape
41
116260
2000
就是蛋白质会改变形态
01:58
and lose their ability to chemically function.
42
118260
3000
失去它们化学性功能
02:01
So I combined these two ideas and I formulated a hypothesis,
43
121260
3000
所以,我将两种想法综合在一起,创造了一个假说,
02:04
saying that, could possibly
44
124260
2000
那就是,很可能的
02:06
the carcinogens be decreased due to a marinade
45
126260
3000
致癌物因为腌泡汁的浸泡而降低
02:09
and could it be due to the differences in PH?
46
129260
2000
是因为酸碱度的改变?
02:11
So my idea was born,
47
131260
2000
这就是我的想法诞生的过程,
02:13
and I had the project set up and a hypothesis,
48
133260
2000
然后,我就有了项目的开展和假说,
02:15
so what was my next step?
49
135260
2000
那么我的下一步呢?
02:17
Well obviously I had to find a lab to work at
50
137260
2000
很明显的,我要找到一家实验室
02:19
because I didn't have the equipment in my school.
51
139260
3000
因为我在学校没有实验设备。
02:22
I thought this would be easy,
52
142260
2000
我以为这会很容易,
02:24
but I emailed about 200 different people
53
144260
2000
但是我给200多个人写邮件
02:26
within a five-hour radius of where I lived,
54
146260
2000
离我居住的地方开车5个小时的范围内,
02:28
and I got one positive response that said that they could work with me.
55
148260
3000
我只得到了一个正面的回复,说愿意帮助我。
02:31
Most of the others either never responded back,
56
151260
2000
更多的人要么根本不回复,
02:33
said they didn't have the time
57
153260
2000
说他们没时间
02:35
or didn't have the equipment and couldn't help me.
58
155260
2000
要么就是没有设备,帮不了我。
02:37
So it was a big commitment
59
157260
2000
所以说,这是一个很重的承诺
02:39
to drive to the lab to work multiple times.
60
159260
3000
要多次开车去实验室开展实验
02:42
However, it was a great opportunity to work in a real lab --
61
162260
2000
但是,这是一个可以在真正的实验室工作的绝好机会--
02:44
so I could finally start my project.
62
164260
2000
我也得以最终开始我的项目
02:46
The first stage was completed at home,
63
166260
2000
第一步是完全在家完成的,
02:48
which consisted of marinating the chicken,
64
168260
2000
其中包括腌制鸡肉,
02:50
grilling the chicken, amassing it
65
170260
2000
烤鸡,收集样本
02:52
and preparing it to be transported to the lab.
66
172260
3000
以及准备送到实验室
02:55
The second stage was completed
67
175260
2000
第二步的完成
02:57
at the Penn State University main campus lab,
68
177260
2000
是在宾州大的主校园实验室,
02:59
which is where I extracted the chemicals,
69
179260
2000
也就是我提取化学物质的地方,
03:01
changed the PH so I could run it through the equipment
70
181260
2000
改变酸碱度,这样我就可以通过设备
03:03
and separated the compounds I needed
71
183260
2000
从其余的鸡肉中
03:05
from the rest of the chicken.
72
185260
2000
分离我所需的成分
03:07
The final stages, when I ran the samples
73
187260
2000
最后一步是,当我把样本
03:09
through a high-pressure
74
189260
2000
经过高压
03:11
liquid chromatography mass spectrometer,
75
191260
3000
液相色谱质谱仪,
03:14
which separated the compounds and analyzed the chemicals
76
194260
3000
分开混和物质,并且分析其中的化学物质
03:17
and told me exactly how much carcinogens I had
77
197260
2000
于是我能很准确得知道在鸡肉中
03:19
in my chicken.
78
199260
2000
有多少致癌物
03:21
So when I went through the data, I had very surprising results,
79
201260
3000
当分析数据时,我发现了很惊人的结果,
03:24
because I found that four out of the five marinating ingredients
80
204260
3000
因为我发现五种腌制调料中有四种
03:27
actually inhibited the carcinogen formation.
81
207260
2000
实际上能阻止致癌物的组成
03:29
When compared with the unmarinated chicken,
82
209260
2000
当同没有经过腌制的鸡肉比较时,
03:31
which is what I used as my control,
83
211260
3000
也就是我的控制样本,
03:34
I found that lemon juice worked by far the best,
84
214260
2000
我发现柠檬汁目前是最有效的,
03:36
which decreased the carcinogens
85
216260
2000
能降低致癌物
03:38
by about 98 percent.
86
218260
2000
达98%
03:40
The saltwater marinade and the brown sugar marinade
87
220260
3000
盐水腌制和红糖腌制
03:43
also worked very well,
88
223260
2000
也同样有效,
03:45
decreasing the carcinogens by about 60 percent.
89
225260
2000
能降低致癌物达60%
03:47
Olive oil slightly decreased the PhIP formation,
90
227260
3000
橄榄油只能轻微的降低PhIP的组成,
03:50
but it was nearly negligible.
91
230260
2000
但是几乎是微不足道的
03:52
And the soy sauce results were inconclusive
92
232260
2000
酱油的实验结果还是未知数
03:54
because of the large data range,
93
234260
2000
这是由于广泛的数据范围,
03:56
but it seems like soy sauce
94
236260
2000
但是看上去,酱油
03:58
actually increased the potential carcinogens.
95
238260
2000
实际上增加了潜在的致癌物
04:00
Another important factor that I didn't take into account initially
96
240260
2000
另一个我没有事先预计在内的重要因素就是
04:02
was the time cooked.
97
242260
2000
烧烤时间
04:04
And I found that if you increase the time cooked,
98
244260
2000
我发现如果增加烧烤时间,
04:06
the amount of carcinogens rapidly increases.
99
246260
3000
致癌物将飞速的增长
04:09
So the best way to marinate chicken, based on this,
100
249260
3000
所以最好的腌制方式,根据这些(实验结果)
04:12
is to, not under-cook,
101
252260
2000
也就是,不要生煮,
04:14
but definitely don't over-cook and char the chicken,
102
254260
2000
但是一定不要煮过头和烤过头,
04:16
and marinate in either lemon juice, brown sugar or saltwater.
103
256260
4000
用柠檬汁,红糖或者盐水来腌制
04:21
(Applause)
104
261260
5000
(掌声)
04:26
Based on these findings, I have a question for you.
105
266260
3000
根据这些发现,我有个问题想问你们
04:29
Would you be willing to make a simple change in your diet
106
269260
3000
你们会愿意在你的饮食上做个简单的改变
04:32
that could potentially save your life?
107
272260
2000
由此可能会拯救你的生命?
04:34
Now I'm not saying that if you eat grilled chicken that's not marinated,
108
274260
2000
我并不是说如果你吃没有经过腌制的烤鸡
04:36
you're definitely going to catch cancer and die.
109
276260
2000
你就一定会得癌症然后死去
04:38
However, anything you can do
110
278260
2000
但是,你所做的任何事情
04:40
to decrease the risk of potential carcinogens
111
280260
2000
来降低潜在致癌物质的几率
04:42
can definitely increase the quality of lifestyle.
112
282260
3000
一定会增加你生活方式的质量
04:45
Is it worth it to you?
113
285260
2000
对你来说,这值得吗?
04:47
How will you cook your chicken now?
114
287260
2000
现在你会怎么做鸡肉呢?
04:49
(Applause)
115
289260
16000
(掌声)
05:05
Shree Bose: Hi everyone. I'm Shree Bose.
116
305260
2000
斯里·波色: 大家好,我是斯里·波色
05:07
I was the 17-18 year-old age category winner
117
307260
2000
我是17-18岁组的冠军
05:09
and then the grand prize winner.
118
309260
3000
也是大奖得主
05:12
And I want all of you
119
312260
2000
我希望你们所有人
05:14
to imagine a little girl
120
314260
2000
想象一个小女孩
05:16
holding a dead blue spinach plant.
121
316260
3000
拿着一个死亡的蓝色菠菜
05:19
And she's standing in front of you and she's explaining to you
122
319260
3000
她就站在你面前,向你解释
05:22
that little kids will eat their vegetables
123
322260
2000
小孩会吃蔬菜
05:24
if they're different colors.
124
324260
2000
如果它们的颜色是不同的
05:26
Sounds ridiculous, right.
125
326260
2000
这挺起来很不可思议,是吧
05:28
But that was me years ago.
126
328260
2000
但这是几年前的我
05:30
And that was my first science fair project.
127
330260
3000
那是我第一个科学展项目
05:33
It got a bit more complicated from there.
128
333260
3000
从那以后就变得复杂了
05:36
My older brother Panaki Bose
129
336260
2000
我的哥哥帕纳吉·波色
05:38
spent hours of his time explaining atoms to me
130
338260
3000
花了很多时间跟我解释原子
05:41
when I barely understood basic algebra.
131
341260
3000
当我还对基本代数没什么概念的时候
05:44
My parents suffered through many more of my science fair projects,
132
344260
3000
我的科学展项目给我的父母带来了很多困扰,
05:47
including a remote controlled garbage can.
133
347260
2000
包括了一个遥控移动垃圾箱
05:49
(Laughter)
134
349260
2000
(笑声)
05:51
And then came the summer after my freshman year,
135
351260
3000
然后就迎来了我高一的暑假,
05:54
when my grandfather passed away due to cancer.
136
354260
3000
也是我爷爷因为癌症去世的时候
05:57
And I remember watching my family go through that
137
357260
2000
我记得看着家人们承受这些痛苦,
05:59
and thinking that I never wanted another family
138
359260
3000
想着我永远都不要别的家庭
06:02
to feel that kind of loss.
139
362260
3000
也经受这种失去
06:05
So, armed with all the wisdom
140
365260
2000
所以,用高一生物知识
06:07
of freshman year biology,
141
367260
2000
来武装起来,
06:09
I decided I wanted to do cancer research
142
369260
3000
在我15岁的时候
06:12
at 15.
143
372260
2000
我决定研究癌症
06:14
Good plan.
144
374260
2000
这是个很棒的计划
06:16
So I started emailing all of these professors in my area
145
376260
2000
所以,我开始向这个领域的所有教授写信
06:18
asking to work under their supervision in a lab.
146
378260
4000
询问能否在他们的监督下在实验室工作。
06:22
Got rejected by all except one.
147
382260
2000
除了一位,其它的全都拒绝了我
06:24
And then went on, my next summer,
148
384260
2000
就这样,在第二个暑假,
06:26
to work under Dr. Basu
149
386260
2000
在位于得克萨斯州华兹堡市的UNT健康中心
06:28
at the UNT Health Center at Fort Worth, Texas.
150
388260
3000
我开始了在巴苏博士的指导下工作
06:31
And that is where the research began.
151
391260
3000
那里就是研究如何开始的
06:34
So ovarian cancer
152
394260
2000
卵巢癌
06:36
is one of those cancers that most people don't know about,
153
396260
3000
是大多数人所不了解的癌症之一,
06:39
or at least don't pay that much attention to.
154
399260
3000
或者至少说没有怎么注意
06:42
But yet, it's the fifth leading cause of cancer deaths
155
402260
3000
但是,它是导致全美女性
06:45
among women in the United States.
156
405260
3000
死亡的第五大癌症
06:48
In fact, one in 70 women
157
408260
2000
实际上,在70位女性中就有一位
06:50
will be diagnosed with ovarian cancer.
158
410260
2000
会被确诊为卵巢癌
06:52
One in 100
159
412260
2000
在100位中就有一位
06:54
will die from it.
160
414260
2000
会因此而死亡
06:56
Chemotherapy, one of the most effective ways
161
416260
2000
化疗,是现今治疗癌症
06:58
used to treat cancer today,
162
418260
2000
最有效的方式之一,
07:00
involves giving patients really high doses of chemicals
163
420260
2000
包括给病患者高剂量的化学物质
07:02
to try and kill off cancer cells.
164
422260
3000
意图杀死癌症细胞
07:05
Cisplatin is a relatively common
165
425260
2000
顺铂是较常见的一种
07:07
ovarian cancer chemotherapy drug --
166
427260
3000
治疗卵巢癌的药--
07:10
a relatively simple molecule made in the lab
167
430260
3000
在实验室中能合成的较简单的分子
07:13
that messes with the DNA of cancer cells
168
433260
2000
它能够捣毁癌症细胞的DNA
07:15
and causes them to kill themselves.
169
435260
2000
促使它们杀死它们自己
07:17
Sounds great, right?
170
437260
2000
挺起来很棒,是吧?
07:19
But here's the problem:
171
439260
2000
但是有个问题:
07:21
sometimes patients become resistant to the drug,
172
441260
3000
有些时候,病人们会对药产生抗药性,
07:24
and then years after they've been declared to be cancer free,
173
444260
3000
许多年后,在癌症被除去之后
07:27
they come back.
174
447260
2000
又重新患上
07:29
And this time, they no longer respond to the drug.
175
449260
2000
但是这次,病人们不会再对药物产生反应
07:31
It's a huge problem.
176
451260
2000
这是个大问题
07:33
In fact, it's one of the biggest problems
177
453260
2000
实际上,这是现今化疗
07:35
with chemotherapy today.
178
455260
2000
所面临的最大的问题之一
07:37
So we wanted to figure out
179
457260
2000
我们想清楚的是
07:39
how these ovarian cancer cells are becoming resistant
180
459260
3000
卵巢癌细胞是如何对这种叫顺铂的药
07:42
to this drug called Cisplatin.
181
462260
2000
产生抗药性
07:44
And we wanted to figure this out,
182
464260
2000
我们之所以想知道这个,
07:46
because if we could figure that out,
183
466260
2000
是因为如果我们把这个搞清楚了,
07:48
then we might be able to prevent that resistance from ever happening.
184
468260
3000
我们可能可以预防抗药性的发生。
07:51
So that's what we set out to do.
185
471260
2000
所以这就是我们要做的
07:53
And we thought it had something to do with this protein called AMP kinase,
186
473260
3000
我们认为跟一种叫做AMP的激酶蛋白有关,
07:56
an energy protein.
187
476260
2000
一种能量蛋白
07:58
So we ran all of these tests blocking the protein,
188
478260
3000
我们进行了很多实验来阻止这种蛋白,
08:01
and we saw this huge shift.
189
481260
2000
我们发现了巨大的改变。
08:03
I mean, on the slide, you can see
190
483260
2000
我的意思是,在幻灯片上,你可以看到
08:05
that on our sensitive side,
191
485260
2000
在我们敏感细胞里,
08:07
these cells that are responding to the drug,
192
487260
2000
这些对药产生反应的细胞,
08:09
when we start blocking the protein,
193
489260
2000
当我们开始阻止这种蛋白,
08:11
the number of dying cells -- those colored dots --
194
491260
3000
死亡细胞的数量--这些有颜色的点--
08:14
they're going down.
195
494260
2000
开始下降
08:16
But then on this side, with the same treatment,
196
496260
3000
但是,在这边,同样的治疗方式,
08:19
they're going up -- interesting.
197
499260
3000
数量在上升--真有趣
08:22
But those are dots on a screen for you;
198
502260
2000
但是那些你们看起来是屏幕上的点;
08:24
what exactly does that mean?
199
504260
2000
到底有什么意义呢?
08:26
Well basically that means
200
506260
2000
基本上,这意味着
08:28
that this protein is changing
201
508260
2000
这种蛋白在改变
08:30
from the sensitive cell to the resistant cell.
202
510260
2000
从敏感细胞变为抵抗性细胞
08:32
And in fact, it might be changing the cells themselves
203
512260
4000
实际上,可能是细胞自身在改变
08:36
to make the cells resistant.
204
516260
3000
让细胞自己变得具有抵抗性
08:39
And that's huge.
205
519260
2000
巨大的(抵抗力)
08:41
In fact, it means that if a patient comes in
206
521260
2000
实际上,这意味着如果病人来
08:43
and they're resistant to this drug,
207
523260
2000
他们对这种药产生抗药性,
08:45
then if we give them a chemical to block this protein,
208
525260
3000
如果我们给他们这种化学物质来阻止这种蛋白,
08:48
then we can treat them again
209
528260
2000
那么我们又可以用同样的药
08:50
with the same drug.
210
530260
2000
重新治疗他们
08:52
And that's huge for chemotherapy effectiveness --
211
532260
3000
对于化疗的有效性来说这是巨大的改变--
08:55
possibly for many different types of cancer.
212
535260
4000
很可能对多种不同的癌症有效
08:59
So that was my work,
213
539260
2000
这就是我的工作,
09:01
and it was my way of reimagining the future
214
541260
3000
这就是我对未来的畅想
09:04
for future research, with figuring out exactly what this protein does,
215
544260
4000
对未来研究的畅想,要弄清楚这种蛋白到底是什么,
09:08
but also for the future of chemotherapy effectiveness --
216
548260
3000
同时也是化疗有效性的未来--
09:11
so maybe all grandfathers with cancer
217
551260
3000
或许所有患有癌症的爷爷
09:14
have a little bit more time to spend with their grandchildren.
218
554260
3000
都能有更多的时间跟他们的孙子辈们在一起
09:17
But my work wasn't just about the research.
219
557260
4000
但是,我的工作并不仅仅是研究
09:21
It was about finding my passion.
220
561260
3000
还包括寻找我的梦想所在
09:24
That's why being the grand prize winner
221
564260
2000
那就是为什么成为谷歌科技展
09:26
of the Google Global Science Fair --
222
566260
2000
大奖的得主--
09:28
cute picture, right --
223
568260
2000
很漂亮的照片,是吧--
09:30
it was so exciting to me and it was such an amazing honor.
224
570260
3000
对于我来说是无比的兴奋,无比的荣耀
09:33
And ever since then,
225
573260
2000
从那以后,
09:35
I've gotten to do some pretty cool stuff --
226
575260
2000
我能开始做很多很酷的东西--
09:37
from getting to meet the president
227
577260
2000
从能够见到总统
09:39
to getting to be on this stage
228
579260
2000
到能站在这个演讲台上
09:41
to talk to all of you guys.
229
581260
2000
跟大家讲话
09:43
But like I said, my journey wasn't just about the research,
230
583260
3000
但是就像我说过的,我的旅行并不仅仅是关于研究,
09:46
it was about finding my passion,
231
586260
2000
也是关于我的梦想,
09:48
and it was about making my own opportunities
232
588260
2000
当我都还不知道我在做什么的时候
09:50
when I didn't even know what I was doing.
233
590260
3000
我如何制造机会
09:53
It was about inspiration
234
593260
2000
这就是灵感
09:55
and determination
235
595260
2000
和决心
09:57
and never giving up on my interest
236
597260
2000
以及从不放弃我
09:59
for science and learning and growing.
237
599260
3000
对自然科学,学习,以及成长的兴趣
10:02
After all, my story begins
238
602260
3000
不管怎样,我的故事始于
10:05
with a dried, withered spinach plant
239
605260
2000
一颗干枯的,凋萎的菠菜
10:07
and it's only getting better from there.
240
607260
2000
从那以后就开始变得越来越好
10:09
Thank you.
241
609260
2000
谢谢大家
10:11
(Applause)
242
611260
10000
(掌声)
10:23
Naomi Shah: Hi everyone. I'm Naomi Shah,
243
623260
3000
劳伦·霍奇:大家好,我是劳伦·霍奇,
10:26
and today I'll be talking to you about my research
244
626260
2000
今天我要跟你们讲讲我
10:28
involving indoor air quality
245
628260
2000
关于室内空气质量的研究
10:30
and asthmatic patients.
246
630260
2000
和哮喘病人
10:32
1.6 million deaths worldwide.
247
632260
3000
在世界范围内有160万,
10:35
One death every 20 seconds.
248
635260
3000
每20秒就有一例死亡
10:38
People spend over 90 percent of their lives indoors.
249
638260
4000
人们90%的生活都在室内
10:42
And the economic burden of asthma
250
642260
2000
哮喘带来的经济负担
10:44
exceeds that of HIV and tuberculosis combined.
251
644260
3000
超过了HIV和肺结核的总合
10:47
Now these statistics had a huge impact on me,
252
647260
3000
这些统计数据对我产生了重大的影响,
10:50
but what really sparked my interest in my research
253
650260
3000
但是,真正点燃我研究兴趣的是
10:53
was watching both my dad and my brother
254
653260
2000
看到我爸爸和弟弟
10:55
suffer from chronic allergies year-round.
255
655260
2000
受到全年慢性过敏的困扰
10:57
It confused me;
256
657260
2000
这让我很困惑;
10:59
why did these allergy symptoms persist
257
659260
2000
为什么这些过敏症状
11:01
well past the pollen season?
258
661260
2000
在花粉季节这么顽固?
11:03
With this question in mind, I started researching,
259
663260
3000
带着这个问题,我开始了研究,
11:06
and I soon found that indoor air pollutants were the culprit.
260
666260
3000
我很快发现室内空气污染物是罪魁祸首
11:09
As soon as I realized this,
261
669260
2000
我一发现这一点,
11:11
I investigated the underlying relationship
262
671260
2000
就调查了
11:13
between four prevalent air pollutants
263
673260
2000
四种广布的空气污染物的关系
11:15
and their affect on the lung health of asthmatic patients.
264
675260
3000
和他们对哮喘病人肺部健康的影响
11:18
At first, I just wanted to figure out
265
678260
3000
起初,我只是想弄清楚
11:21
which of these four pollutants have the largest negative health impact
266
681260
3000
这四种污染物中哪一种对于哮喘病人的肺部健康来说
11:24
on the lung health of asthmatic patients.
267
684260
3000
是最有害的
11:27
But soon after, I developed a novel mathematical model
268
687260
3000
但是很快,我建立了一个新型的数学模型
11:30
that essentially quantifies the effect
269
690260
2000
从本质上量化了
11:32
of these environmental pollutants
270
692260
3000
这些环境污染物
11:35
on the lung health of asthmatic patients.
271
695260
2000
对哮喘病人肺部健康的影响
11:37
And it surprises me
272
697260
2000
让我惊奇的是
11:39
that no model currently exists
273
699260
2000
目前还没有模型
11:41
that quantifies the effect of environmental factors
274
701260
2000
能量化环境因素对
11:43
on human lung health,
275
703260
2000
人类肺部健康的影响,
11:45
because that relationship seems so important.
276
705260
3000
因为这之间的关系看起来很重要
11:48
So with that in mind,
277
708260
2000
带着这种想法,
11:50
I started researching more, I started investigating more,
278
710260
2000
我开始了更多的研究,更多的调查,
11:52
and I became very passionate.
279
712260
2000
变得激情澎湃
11:54
Because I realized
280
714260
2000
因为,我发现
11:56
that if we could find a way to target remediation,
281
716260
2000
如果我们能找到一个整治环境的方法,
11:58
we could also find a way
282
718260
2000
我们也能找到一种方法
12:00
to treat asthmatic patients more effectively.
283
720260
4000
来更有效的治疗哮喘病人
12:04
For example, volatile organic compounds
284
724260
2000
比如,挥发性有机物
12:06
are chemical pollutants
285
726260
2000
是化学性污染物
12:08
that are found in our schools, homes and workplaces.
286
728260
2000
在我们的学校,家里以及办公室都能发现
12:10
They're everywhere.
287
730260
2000
它们无处不在
12:12
These chemical pollutants
288
732260
2000
这些化学污染物
12:14
are currently not a criteria air pollutant,
289
734260
2000
据美国清洁空气法案定义
12:16
as defined by the U.S. Clean Air Act.
290
736260
2000
目前还不在空气污染物的标准中
12:18
Which is surprising to me,
291
738260
2000
这让我感到惊奇,
12:20
because these chemical pollutants, through my research,
292
740260
2000
因为这些化学污染物,根据我的研究,
12:22
I show that they had a very large negative impact
293
742260
3000
我发现他们对哮喘病人的健康
12:25
on the lung health of asthmatic patients
294
745260
2000
有极其负面的影响
12:27
and thus should be regulated.
295
747260
2000
因此应该被列入规范中
12:29
So today I want to show you
296
749260
2000
所以今天我想向你们展示
12:31
my interactive software model that I created.
297
751260
3000
我创造的互动软件
12:34
I'm going to show it to you on my laptop.
298
754260
2000
我将用我的笔记本电脑向大家展示
12:36
And I have a volunteer subject in the audience today,
299
756260
2000
在今天的观众中,我有一个志愿者
12:38
Julie.
300
758260
2000
朱莉
12:40
And all of Julie's data has been pre-entered
301
760260
3000
朱莉的所有数据都被事先输入
12:43
into my interactive software model.
302
763260
2000
进我的交互软件模型中
12:45
And this can be used by anyone.
303
765260
2000
这个模型可以用在任何人身上
12:47
So I want you to imagine that you're in Julie's shoes,
304
767260
2000
现在我希望大家以朱莉的身份来想象,
12:49
or someone who's really close to you
305
769260
2000
或者跟你最亲近
12:51
who suffers from asthma or another lung disorder.
306
771260
3000
患有哮喘病或者其他肺部疾病的人
12:54
So Julie's going to her doctor's office
307
774260
2000
朱莉现在去看医生
12:56
to get treated for her asthma.
308
776260
2000
去治疗她的哮喘
12:58
And the doctor has her sit down,
309
778260
2000
医生请她坐下,
13:00
and he takes her peak expiratory flow rate --
310
780260
3000
给她测了呼气流量率峰值--
13:03
which is essentially her exhalation rate,
311
783260
2000
实际上是她的呼气率,
13:05
or the amount of air that she can breathe out in one breath.
312
785260
3000
或者说是她一口气所呼出的空气量
13:08
So that peak expiratory flow rate,
313
788260
2000
所以说呼气流量率峰值,
13:10
I've entered it up into the interactive software model.
314
790260
2000
我把这个值输入交互软件模型中
13:12
I've also entered in her age, her gender and her height.
315
792260
3000
我也输入了她的年龄,性别和身高
13:15
I've assumed that she lives in an average household
316
795260
2000
我还假设她住在一个普通环境
13:17
with average air pollutant levels.
317
797260
2000
处于普通的空气污染程度
13:19
So any user can come in here
318
799260
2000
任何用户可以用这个软件
13:21
and click on "lung function report"
319
801260
2000
点击“肺部功能报告”
13:23
and it'll take them to this report that I created.
320
803260
2000
它就能告诉他们我发明的这个报告
13:25
And this report really drives home the crux of my research.
321
805260
4000
这个报告真真切切的促进了我研究中的症结
13:29
So what it shows -- if you want to focus on that top graph in the right-hand corner --
322
809260
4000
它显示出--如果你只想关注右上角的图示--
13:33
it shows Julie's actual peak expiratory flow rate
323
813260
2000
它显示出朱莉的实际呼气流量率峰值
13:35
in the yellow bar.
324
815260
2000
就是那个黄色方块
13:37
This is the measurement that she took in her doctor's office.
325
817260
3000
这个是她在医生那里的测量值
13:40
In the blue bar at the bottom of the graph,
326
820260
2000
在图示下方的蓝色方块,
13:42
it shows what her peak expiratory flow rate,
327
822260
3000
显示了她的呼气流量率峰值,
13:45
what her exhalation rate or lung health, should be
328
825260
2000
她的析出率或者肺部健康,应该是
13:47
based on her age, gender and height.
329
827260
3000
根据她的年龄,性别和身高
13:50
So the doctor sees this difference between the yellow bar and the blue bar,
330
830260
3000
所以当医生看到黄色方块和蓝色方块的区别,
13:53
and he says, "Wow, we need to give her steroids,
331
833260
3000
他会说,“哇,我们应该给她类固醇,
13:56
medication and inhalers."
332
836260
3000
药品和气管喷雾。”
13:59
But I want everyone here to reimagine a world
333
839260
3000
我希望大家重新想象一下一个世界
14:02
where instead of prescribing steroids,
334
842260
2000
一个没有处方类固醇,
14:04
inhalers and medication,
335
844260
2000
气管喷雾和药品,
14:06
the doctor turns to Julie and says,
336
846260
2000
医生会对朱莉说,
14:08
"Why don't you go home and clean out your air filters.
337
848260
2000
“为什么你不回家清理一下你家的空气过滤器呢
14:10
Clean out the air ducts in your home,
338
850260
2000
清扫你家的灰尘,
14:12
in your workplace, in your school.
339
852260
2000
在你办公室,以及你学校的灰尘。
14:14
Stop the use of incense and candles.
340
854260
3000
不要用熏香和蜡烛
14:17
And if you're remodeling your house,
341
857260
2000
如果你要重建你家,
14:19
take out all the carpeting and put in hardwood flooring."
342
859260
3000
把所有的地毯都撤掉,换成木地板吧。”
14:22
Because these solutions are natural,
343
862260
2000
因为这些解决方法都是天然的,
14:24
these solutions are sustainable,
344
864260
2000
这些解决方法都是可持续的,
14:26
and these solutions are long-term investments --
345
866260
3000
这些解决方法是种长期的投资--
14:29
long-term investments that we're making
346
869260
2000
我们为了我们这一代人
14:31
for our generation and for future generations.
347
871260
2000
以及未来的人做的长期投资
14:33
Because these environmental solutions
348
873260
3000
因为这些环境的解决方法
14:36
that Julie can make in her home, her workplace and her school
349
876260
3000
这些朱莉在她的家,她的工作室和她的学校就可以实施的解决方法
14:39
are impacting everyone that lives around her.
350
879260
3000
对生活在他周围的每一个人产生了影响
14:42
So I'm very passionate about this research
351
882260
2000
所以我对这项研究非常热情
14:44
and I really want to continue it
352
884260
2000
我非常希望能够继续研究
14:46
and expand it to more disorders besides asthma,
353
886260
3000
将它扩展到除了哮喘病之外的更多的疾病,
14:49
more respiratory disorders, as well as more pollutants.
354
889260
3000
更多的呼吸系统疾病,以及更多的污染物
14:52
But before I end my talk today,
355
892260
2000
在我结束今天的讲话之前,
14:54
I want to leave you with one saying.
356
894260
2000
我想以一句话结束
14:56
And that saying is that genetics loads the gun,
357
896260
3000
这句话就是遗传学将子弹装上,
14:59
but the environment pulls the trigger.
358
899260
2000
但是环境扣下扳机
15:01
And that made a huge impact on me
359
901260
2000
当我在进行研究的时候
15:03
when I was doing this research.
360
903260
2000
那对我产生了巨大的影响
15:05
Because what I feel, is a lot of us think
361
905260
2000
因为我感觉到的是,我们很多人都认为
15:07
that the environment is at a macro level,
362
907260
3000
环境是一个很大的范围,
15:10
that we can't do anything to change our air quality
363
910260
2000
对于改变空气质量,我们做不了什么
15:12
or to change the climate or anything.
364
912260
3000
也无法改变气候或者其他任何事。
15:15
But if each one of us takes initiative in our own home,
365
915260
3000
但是如果我们每个人在我们自己家里行动起来,
15:18
in our own school and in our own workplace,
366
918260
3000
在我们的学校,我们的办公室,
15:21
we can make a huge difference in air quality.
367
921260
2000
我们能极大得改变空气质量
15:23
Because remember, we spend 90 percent of our lives indoors.
368
923260
4000
因为请记住,我们百分之九十的生活都是在室内
15:27
And air quality and air pollutants
369
927260
3000
空气质量和空气污染物
15:30
have a huge impact on the lung health of asthmatic patients,
370
930260
3000
对哮喘病人的肺部健康有巨大的影响,
15:33
anyone with a respiratory disorder
371
933260
2000
以及任何患有呼吸系统紊乱的人
15:35
and really all of us in general.
372
935260
2000
和实际上我们所有人
15:37
So I want you to reimagine a world
373
937260
2000
我想让你们重新想象一个世界
15:39
with better air quality,
374
939260
2000
充满更优质的空气,
15:41
better quality of life
375
941260
2000
更优质的生活
15:43
and better quality of living for everyone
376
943260
2000
和对于每个人来说都是更好的生活环境
15:45
including our future generations.
377
945260
2000
包括我们未来的后代们
15:47
Thank you.
378
947260
2000
谢谢
15:49
(Applause)
379
949260
7000
(鼓掌)
15:56
Lisa Ling: Right.
380
956260
2000
丽莎 林:好
15:58
Can I have Shree and Lauren come up really quickly?
381
958260
5000
请允许我邀请斯里和劳伦一起上台来
16:03
Your Google Science Fair champions.
382
963260
2000
你们是谷歌全球科学展的胜利者
16:05
Your winners.
383
965260
2000
你们是冠军
16:07
(Applause)
384
967260
3000
(鼓掌)
关于本网站

这个网站将向你介绍对学习英语有用的YouTube视频。你将看到来自世界各地的一流教师教授的英语课程。双击每个视频页面上显示的英文字幕,即可从那里播放视频。字幕会随着视频的播放而同步滚动。如果你有任何意见或要求,请使用此联系表与我们联系。

https://forms.gle/WvT1wiN1qDtmnspy7