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翻译人员: Cissy Yun
校对人员: Zongzhen Yang
00:06
It's so obvious
that it's practically proverbial.
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很明显又众所周知的是
00:09
You can't unboil an egg.
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你不能把一个熟蛋变生
00:12
Well, it turns out you can, sort of.
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然而,其实在某种程度上,
你是可以的
00:15
What thermal energy
does to the eggs' molecules,
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热能对蛋的分子所做的事
00:18
mechanical energy can undo.
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机械能可以将其还原
00:21
Eggs are mostly made
of water and proteins.
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蛋主要是由水和蛋白质组成
00:24
The proteins start off
folded up into intricate shapes,
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蛋白质最开始折叠成一种复杂的形状
00:28
held together by weak chemical bonds.
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依靠弱的化学键连接在一起
00:31
Adding heat disrupts those bonds,
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加热能分解化学键
00:33
allowing the proteins to unfold,
uncoil, unwind and wiggle freely.
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使的蛋白质展开,松绕,分离,
变得可以移动
00:39
This process is called denaturing.
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这个过程被称为“改性”
00:42
The newly liberated proteins
bump up against their neighbors
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新的被解放的蛋白质互相撞击
00:45
and start to form
new bonds with each other,
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并在其中形成新的化学键
00:48
more and more as the heat increases,
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当热量变得越来越多后
00:51
until finally, they're so entangled
that they gel into a solid mass,
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到达某一刻时,蛋白质之间的精密缠绕,
最终形成一个固体
00:56
a boiled egg.
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就是煮熟的蛋
00:58
That entanglement might look
permanent, but it's not.
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这个过程可能看起来不可逆,
但其实不是的
01:01
According to a chemical idea
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根据一个叫做
01:03
called the principle
of microscopic reversibility,
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微观可逆原理的化学观点
01:06
anything that happens,
like egg proteins seizing up,
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任何已发生的,
比如说鸡蛋中的蛋白质变为固体的情况
01:10
can theoretically unhappen
if you retrace your steps.
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如果你反之重复每一步,理论上可以反转
01:14
But adding more heat will tangle
the proteins further,
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但增加更多的热量会使蛋白质纠缠的更紧
01:17
and cooling them down
will only freeze them,
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而冷却只会冻住它们
01:20
so here's the trick:
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所以这里的窍门是
01:22
spin them around ridiculously fast.
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将其极快的旋转
01:25
I'm not kidding.
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我没在开玩笑
01:26
Here's how it works.
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它们是这样做的
01:28
First, scientists dissolve
boiled egg whites in water
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首先,科学夹将煮熟的蛋白溶解在水中
01:31
with a chemical called urea,
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加以一种化学物质,尿素
01:33
a small molecule that acts as a lubricant,
coating the proteins' long strands
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它是一个小分子,被用作润滑剂,
涂上蛋白质较长的一股
01:38
and making it easier for them
to glide past each other.
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使得它们更容易得滑过对方
01:42
Then, they spin that solution
in a glass tube
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然后,他们将溶液放入试管以
01:45
at a breakneck 5000 rotations per minute,
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一个极快的5000转每分钟的速度旋转
01:49
making the solution
spread out into a thin film.
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使得溶液展开形成一层很薄的生物膜
01:52
Here's the key part.
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接下来是关键的部分
01:54
The solution nearest
the wall spins faster
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离试管壁最近的溶液旋转地比
01:57
than the solution closer to the middle.
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中间的溶液旋转得快
01:59
That difference in velocity
creates sheer stresses
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这个速度上的区别产生了剪应力
02:03
that repeatedly stretch
and contract the proteins
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会重复拉伸和收缩蛋白质
02:06
until eventually they snap back
into their native shapes and stay there.
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直到最后它们恢复成原始的性状,
并稳定下来
02:12
By the time the centrifuge stops spinning,
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当离心机停止旋转
02:15
the egg white is back
in its original unboiled state.
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鸡蛋白恢复成了未被煮过的形态
02:20
This technique works
with all sorts of proteins.
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这个技术适用于所有蛋白质
02:23
Bigger, messier proteins can be
more resistant to being pulled apart,
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更大和更混乱的蛋白质将会更难还原
02:27
so scientists attach
a plastic bead to one end
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所以科学家会在蛋白质一股的一端
黏上一个塑料珠
02:31
that adds extra stress
and encourages it to fold up first.
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产生额外的重量,并会加大收缩
促使它先折叠
02:35
This unboiling method won't work
with a whole egg in its shell
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这个方法不适用于一个完整的带壳的蛋
02:40
since the solution has to spread
throughout a cylindrical chamber.
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因为溶液必须在圆柱体容器内展开
02:44
But the applications go way beyond
uncooking your breakfast, anyhow.
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但它的应用远超出仅是还原你的早餐
02:48
Many pharmaceuticals consist of proteins
that are extremely expensive to produce,
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很多含有蛋白质的药物的生产费用非常高
02:53
partly because they get stuck
in tangled up aggregates,
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有些是因为他们卡在了聚集蛋白质中
02:57
just like cooked egg whites
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就像煮熟的蛋白
02:59
and have to be untangled and refolded
before they can do their jobs.
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这些必须在他们开始工作前被打散和展开
03:03
This spinning technique has the potential
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这个旋转方法,
相比于其他再折叠蛋白质的方式
03:06
to be an easier, cheaper
and quicker method
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有着成为一个更简单,便宜,快速的方法
03:09
than other ways to refold proteins,
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的潜力
03:11
so it may allow new drugs to be made
available to more people faster.
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所以,它可能会使新药物的出现更加快捷
03:16
And there's one more thing
you need to keep in mind
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还有一个事情你需要记住
03:18
before trying to uncook all of your food.
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在还原你的食物之前
03:21
Boiling an egg is actually
an unusual cooking process
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煮蛋实际上是个不寻常的过程
03:25
because even though it changes the way
proteins are shaped and bound together,
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因为即使它使蛋白质的形状和连接方式
发生了改变
03:29
it doesn't actually change
their chemical identity.
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它的化学性质并没有改变
03:33
Most types of cooking are more like
the famous Maillard reaction,
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大多数烹饪过程类似著名的“梅拉德反应”
03:36
which makes chemical changes
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就是会发生化学变化
03:38
that turn sugars and proteins
into delicious caramel crunchiness
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将糖分和蛋白质转换成美味的焦糖脆
03:43
and are a lot harder to undo.
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这会非常难还原
03:46
So you might be able to unboil your egg,
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所以你可以还原你的煮蛋
03:48
but I'm sorry to say
you can't unfry it...yet.
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但很抱歉,目前为止,
还不能还原你的煎蛋
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