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譯者: Ya Hui Hung
審譯者: 盧 曉天
(音樂)
00:13
When you think about the brain,
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當你想到大腦
00:15
it's difficult to understand,
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它是個複雜難解的器官
00:17
because if I were to ask you right now,
how does the heart work,
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因為如果我問你
心臟是如何運作
00:20
you would instantly tell me it's a pump.
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你一定能馬上跟我說這是一個泵
它輸送血液
00:23
It pumps blood.
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00:24
If I were to ask about your lungs,
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如果我問你肺是如何運作
你一定知道肺的功能是氧氣和二氧化碳的交流
很簡單對吧
00:26
you would say it exchanges
oxygen for carbon dioxide.
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00:28
That's easy.
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00:29
If I were to ask you how the brain works,
it's hard to understand
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但如果我問你大腦如何運作
這就不容易解釋了
00:32
because you can't just look
at a brain and understand what it is.
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因為它的構造複雜難解
它不是一個機械物體
不是泵,也不是一個氣囊
00:36
It's not a mechanical object,
not a pump, not an airbag.
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00:38
It's just like, if you held it
in your hand when it was dead,
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一個大腦就只是一陀脂肪
00:41
it's just a piece of fat.
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所以要了解大腦的運作
00:43
To understand how the brain works,
you have to go inside a living brain.
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你需要研究活大腦。因為大腦有電性和化學性
00:47
Because the brain's not mechanical,
the brain is electrical and it's chemical.
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不是一個機械物體
00:51
Your brain is made out of
100 billion cells, called neurons.
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你的大腦是由上百億個神經細胞組成的
00:53
And these neurons communicate
with each other with electricity.
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這些神經細胞借由電傳導傳達訊息
00:57
And we're going to eavesdrop
in on a conversation between two cells,
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現在我們要來聽聽神經細胞間的對話
01:01
and we're going to listen
to something called a spike.
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這叫做神經衝動
01:03
But we're not going to record my brain
or your brain or your teachers' brains,
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但我們要用的不是我的、你們的
或你們老師的大腦
01:07
we're going to use our good
friend the cockroach.
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我們要借用我們好友小強 (蟑螂)的
這不是因為蟑螂的大腦很酷
01:10
Not just because I think they're cool,
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01:12
but because they have brains
very similar to ours.
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是因為牠們的大腦類似我們的
01:14
So if you learn a little bit
about how their brains work,
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所以我們可以從了解蟑螂的大腦功能
01:17
we're going to learn a lot
about how our brains work.
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進而認識我們的大腦運作
01:19
I'm going to put them
in some ice water here
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首先我要將蟑螂放入這冰水中
然後...
01:22
And then --
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01:24
Audience: Ew!
Greg Gabe: Yeah ...
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(觀眾: 厭惡聲)...耶...
01:26
Right now they're becoming anesthetized.
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這步驟是將牠們麻醉
01:28
Because they're cold blooded,
they become the temperature of the water
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因為牠們是冷血動物,沒有體內調溫系統
01:31
and they can't control it
so they just basically "chillax," right?
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體溫隨外溫變動,所以牠們現在是冷凍了
01:35
They're not going to feel anything,
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牠們不會有任何感觸
01:37
which may tell you a little
about what we're going to do,
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這提示了一點我們將要做甚麼
01:39
a scientific experiment
to understand the brain.
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我們將要做一個了解大腦的科學實驗
01:42
So ...
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這樣...
01:44
This is the leg of a cockroach.
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這是一條蟑螂腿
01:46
And a cockroach
has all these beautiful hairs
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蟑螂有好多美麗的毛髮
01:48
and pricklies all over it.
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和刺
01:50
Underneath each one of those is a cell,
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這每一個底下都是一個細胞
01:53
and this cell's a neuron
that is going to send information
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這一個是神經細胞
能傳達風向或震動的訊息
01:56
about wind or vibration.
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蟑螂不好抓是因為
01:57
If you ever try to catch a cockroach,
it's hard because they can feel you coming
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牠們能感應到你的動作而開始逃跑
02:01
before you're even there,
they start running.
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02:03
These cells are zipping up
this information up to the brain
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這些神經細胞是利用軸突
和電傳導訊息到大腦
02:06
using those little axons
with electronic messages in there.
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我們要用這根針來記錄這訊息
02:09
We're going to record
by sticking a pin right in there.
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首先我們要先將一條蟑螂腿拔下
02:11
We need to take off the leg
of a cockroach --
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02:14
don't worry, they'll grow back --
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別擔心,這會再長回去
02:16
then we're going to put two pins in there.
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然後把這兩根針插這裡
這其中一根鐵針
02:18
These are metal pins.
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02:19
One will pick up this electronic message,
this electric message is going by.
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能接受到這用電傳導的訊息
02:23
So, we're now going to do the surgery,
let's see if you guys can see this.
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現在讓我們來做個小手術,都看得到吧?
的確有點噁心...
02:28
Yeah, it's gross ...
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好了...
02:32
All right. So there we go.
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你們可以看到牠的腿
02:35
You guys can see his leg right there.
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02:37
Now I'm going to take this leg,
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現在我要把這腿放到我們發明的這儀器
02:39
I'm going to put it in this invention
that we came up with
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02:41
called the Spikerbox --
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叫做神經衝動箱
這可以取代很多昂貴的實驗設備
02:43
and this replaces lots of expensive
equipment in a research lab,
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讓你們在自己的中學實驗室也可以做
02:46
so you guys can do this
in your own high schools,
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02:49
or in your own basements if it's me.
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或如果是我的話,我家的地下室
02:53
(Audience: Laughter)
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02:55
So, there.
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好了 (笑聲)
02:59
Can you guys see that?
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看得到嗎? 要開始了
03:01
Alright, so I'm going to go ahead
and turn this on.
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把這插進去 (神經細胞發射聲)
03:06
I'm going to plug it in.
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我覺得這是世上最美妙的聲音
03:08
(Tuning sound)
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03:09
To me, this is the most beautiful
sound in the world.
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你們的大腦現在也正在這麼做
03:11
This is what your brain
is doing right now.
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03:13
You have 100 billion cells
making these raindrop-type noises.
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你們有上百億的神經細胞正在發出這雨滴聲
03:16
Let's take a look at what it looks like,
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讓我們來看看這看起來是如何
03:18
let's pull it up on the iPad screen.
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讓我們用 iPad 看
看這 iPad 的螢幕
03:20
I plugged my iPad into here as well.
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還記得我說過的軸突和電傳導
的神經衝動 (spike) 嗎?
03:22
So remember we said
the axon looks like a spike.
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03:24
So we're going to take a look
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這就是我們等會要看的
03:25
at what one of them
looks like in just a brief second.
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這裡點一下,平均一下這傢伙
03:28
We're going to tap here,
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03:29
so we can sort of average this guy.
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03:31
So there we see it.
That's an action potential.
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這就是動作電位 (action potential)
03:34
You've got 100 billion cells
in your brain doing this right now,
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你們上百億的神經細胞也正是如此運作
03:37
sending all this information back
about what you're seeing, hearing.
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將你們所看和聽到的訊息傳達到大腦
我說過這神經細胞能傳達風向訊息
03:40
We also said this is a cell
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03:41
that's going to be taking up information
about vibrations in the wind.
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03:45
So what if we do an experiment?
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來試驗一下吧
03:46
We can actually blow on this
and hear if we see a change.
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我可以在這吹一下
聽看看有什麼變動
03:49
Are you guys going to be ready?
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準備好了嗎?
03:50
If I blow on it you tell me
if you hear anything.
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我要吹了,跟我說你們聽到了什麼
03:53
(Blowing)
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(隨吹氣變動的神經衝動聲)
03:55
(Sound changes)
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03:57
Let me just touch this
with a little pen here.
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讓我用鉛筆在這裡按一下
03:59
(Noise)
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(雜音)
04:02
That was the neural firing rate.
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這就是神經射程
這是長期的
04:04
That actually took a while
in neuroscience to understand this.
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神經科學研究成果
這叫速率編碼
04:07
This is called rate coding:
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04:08
the harder you press on something,
the more spikes there are,
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當你按的越重
就會有越多的神經衝動
04:11
and all that information
is coming up to your brain.
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傳達信息到你的大腦
這就是你如何感受周遭事物
04:14
That's how you perceive things.
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04:15
So that's one way of doing
an experiment with electricity.
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這是測試電傳導的實驗之一
04:18
The other way is that your brain is not
only taking in electrical impulses,
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大腦在接收訊息的同時也在發出訊息
04:22
you're also sending out.
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例如移動你的手腳
04:24
That's how you move your muscles around.
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現在讓我們來看看把電插到蟑螂腿上
04:26
Let's see what happens if I've plugged in
something that's electric
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會如何
04:29
into the cockroach leg here.
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04:31
I'm going to take two pins,
I'm going to plug them onto the cockroach.
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我將把這兩根針插入這蟑螂
04:34
I'm going to take the other end,
I'm going to plug in into my iPod.
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然後把這另一端插入我的 iPod
04:38
It's my iPhone actually.
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其實這是我的 iPhone
04:39
Do you guys know how your earbuds
work in your ears?
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你們知道耳塞型耳機是如何運作的嗎?
04:42
You have a battery
in your phone, or iPod, right?
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你們都知道手機和 iPod 裡都有電池吧?
04:45
It's sending electrical current
into these magnets in your earbuds
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這利用電流震動耳機內的磁鐵
04:48
which shake back and forth
and allow you to hear things.
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讓你聽得到東西
04:51
But that current's the same currency
that our brain uses,
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大腦裡的電流跟這類似
04:54
so we can send that to our cockroach leg
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讓我用這蟑螂腿來示範
04:55
and hopefully if this works,
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04:57
we can actually see what happens
when we play music into the cockroach.
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放音樂對這腿有什麼影響
05:00
Let's take a look.
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讓我們來看看吧
(音樂) 可以大聲點嗎?
05:03
(Music beat)
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05:05
Can we turn it up? There we go.
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05:07
(Audience reacts and gasps)
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(音樂) (觀眾驚嚇的反應) 這是什麼?
05:10
GG: So what's happening?
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(音樂)
05:11
Audience: Wow!
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05:13
(Laughter)
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它在動
隨著低音在動
05:14
So you see what's moving.
It's moving on the bass.
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05:17
All those audiophiles out there,
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在座的發燒友
如果你有很棒的車內音響
05:19
if you have awesome, kicking car stereos,
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05:21
you know, the bass speakers
are the biggest speakers.
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你們應該都知道低音喇叭最大
05:23
The biggest speakers
have the longest waves,
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最大的喇叭的聲波最長和最多電流
05:26
which have the most current,
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05:27
and the current is what's causing
these things to move.
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電流能造成東西移動
05:30
So it's not just speakers
that are causing electricity.
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除了喇叭能傳導電流
05:33
Microphones also cause electricity.
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麥克風也可以 (音樂節拍)
05:35
(Beat)
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05:36
So I'm going to go ahead and invite
another person out on the stage here
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現在我要請一位幫手出台
05:40
to help me out with this.
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看好了 (節奏口技)
05:41
So there we go.
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05:42
(Beatboxing)
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05:47
This is the first time this has ever
happened in the history of mankind.
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這是世上第一的
05:50
Human beatbox to a cockroach leg.
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隨節奏口技起舞的蟑螂腿
05:53
When you guys go back to your high school,
think about neuroscience
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我希望這能啟發你們
對神經科學的興趣和創新
05:56
and how you guys can begin
the neuro-revolution.
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05:59
Thank you very much. Bye bye.
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謝謝
再見 (掌聲)
06:00
(Applause)
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(音樂)
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