A secret weapon against Zika and other mosquito-borne diseases | Nina Fedoroff

譯者: 易帆 余 審譯者: JieWei Li

Zika fever:

茲卡病毒：

our newest dread disease.

我們最新的可怕疾病。

What is it? Where'd it come from?

它是什麼？從何而來？

What do we do about it?

我們該怎麼應對？

Well for most adults, it's a relatively mild disease --

對多數成年人來說， 它只算是個輕微的小病──

a little fever, a little headache, joint pain, maybe a rash.

只會微微發燒、頭痛、 關節痛、可能會起紅疹。

In fact, most people who get it don't even know they've had it.

實際上，很多得過的人 根本就不知道自己得過這個病。

But the more we find out about the Zika virus

但當我們越了解茲卡病毒，

the more terrifying it becomes.

它就變得越恐怖。

For example, doctors have noticed an uptick

例如，最近醫生發現 在近幾次的疫情爆發中，

of something called Guillain-Barré syndrome in recent outbreaks.

格林—巴利症候群患者 有急速增加的現象。

In Guillain-Barré, your immune system attacks your nerve cells

一旦得了格林—巴利症， 你的免疫系統就會攻擊神經細胞，

it can partially or even totally paralyze you.

它會使你部分或全身癱瘓。

Fortunately, that's quite rare, and most people recover.

還好，這樣的現象很罕見， 大多數人都能痊癒。

But if you're pregnant when you're infected

但如果妳懷孕時染上病毒，

you're at risk of something terrible.

你會遭遇到很恐怖的風險。

Indeed, a child with a deformed head.

沒錯，小孩子的頭部會畸形。

Here's a normal baby.

這是正常的小孩。

Here's that infant with what's called microcephaly.

這是患有小頭畸形的小孩，

a brain in a head that's too small.

頭骨對腦來說太小了。

And there's no known cure.

目前還沒有治癒方法。

It was actually doctors in northeastern Brazil

其實這是由一群 在巴西東北部的醫生，

who first noticed, just a year ago, after a Zika outbreak,

在去年茲卡病毒爆發後首度發現的。

that there was a peak in the incidence of microcephaly.

小頭畸形的案例突然攀升。

It took medical doctors another year

醫生們又用了一年

to be sure that it was caused by the Zika virus,

來確定是不是由 茲卡病毒所引起的症狀。

but they're now sure.

但他們現在已經非常肯定了。

And if you're a "bring on the evidence" type,

如果你是「實事求是」那一型的人，

check out this publication.

可以來看看這篇公開的文章。

So where did it come from, and how did it get here?

怎麼會這樣？到底怎麼傳到這裡的？

And it is here.

這裡的確有病例。

Like many of our viruses, it came out of Africa,

像其他許多病毒一樣， 茲卡病毒是從非洲傳出來的，

specifically the Zika forest in Uganda.

準確來說是烏干達的茲卡森林。

Researchers at the nearby Yellow Fever Research Institute

研究員在黃熱病 調查機構的附近發現，

identified an unknown virus in a monkey in the Zika forest

確診出茲卡森林裡面的猴子 有這個未知病毒。

which is how it got its name.

這就是茲卡病毒命名的由來。

The first human cases of Zika fever

人類的第一件茲卡病例，

surfaced a few years later in Uganda-Tanzania.

是那之後幾年 在烏干達坦尚尼亞間發現。

The virus then spread through West Africa

之後這個病毒傳到西非，

and east through equatorial Asia -- Pakistan, India, Malaysia, Indonesia.

往東傳到亞洲的赤道國家，

像巴基斯坦、印度、 馬來西亞、印尼等國。

But it was still mostly in monkeys and, of course, mosquitoes.

但這病毒仍大多存在猴子身上， 當然還有蚊子身上。

In fact in the 60 years between the time it was first identified in 1947 and 2007

其實在這 60 年間，也就是 1947 年第一次爆發到 2007 年，

there were only 13 reported cases of human Zika fever.

人類染上茲卡病毒的 紀錄只有 13 例，

And then something extraordinary happened on the tiny Micronesian Yap islands.

之後，在密克羅尼西亞的雅浦島上 發生了非常不尋常的事。

There was an outbreak that affected fully 75 percent of the population.

有 75% 的人口都受到感染。

How did it get there? By air.

病毒怎麼傳到那裡的？透過飛機。

Today we have two billion commercial airline passengers.

現在全球有 20 億商業飛行旅客。

An infected passenger can board a plane, fly halfway around the world

一個受感染的乘客上了飛機， 就可以飛過大半個地球，

before developing symptoms -- if they develop symptoms at all.

在這之前，不會有任何症狀。

Then when they land, the local mosquitoes begin to bite them and spread the fever.

一旦他們抵達目的地， 當地的蚊子就會咬他們並擴散病毒，

Zika fever then next surfaced in 2013 in French Polynesia.

茲卡病毒接著於 2013 年 在法屬玻里尼西亞爆發。

By December of that year, it was being transmitted locally by the mosquitoes.

當年12月病毒 就藉由蚊子傳到各地，

That led to an explosive outbreak in which almost 30,000 people were affected.

造成疫情大規模爆發， 近三萬人遭到感染。

From there it radiated around the Pacific.

之後再擴散到整個太平洋地區。

There were outbreaks in the Cook Islands, in New Caledonia,

傳出疫情的地區有 庫克群島、新喀里多尼亞、

in Vanuatu, in the Solomon Islands

萬那杜、所羅門群島，

and almost all the way around to the coast of South America and Easter Island.

幾乎整個南美沿岸和復活島都爆發了。

And then, in early 2015,

接著，在 2015 年年初，

there was an upsurge of cases of a dengue-like syndrome

在巴西東北部的城市納塔爾，

in the city of Natal in northeastern Brazil.

出現了大量疑似染上登革熱的病患。

The virus wasn't dengue, it was Zika, and it spread rapidly --

那不是登革熱病毒，是茲卡， 而且傳播非常迅速。

Recife down the coast, a big metropolitan center, soon became the epicenter.

南岸的大都市勒西菲 也成了下一個疫情中心。

Well people have speculated that it was 2014 World Cup soccer fans

有人猜測是 2014 年的足球杯球迷

that brought the virus into the country.

把病毒帶到巴西。

But others have speculated that perhaps it was Pacific Islanders

但有其他人推測 有可能是太平洋島居民

participating in championship canoe races

在里約舉辦的獨木舟競賽，

that were held in Rio that year that brought it in.

在當年把病毒帶進來的。

Well today, this is only a year later.

現在，才事隔一年。

The virus is being locally transmitted by mosquitoes

病毒就在當地被蚊蟲傳播開來，

virtually throughout South America, Central America, Mexico

幾乎整個南美洲、中美洲、墨西哥、

and the Caribbean Islands

加勒比海群島都被感染了。

Until this year, the many thousands of cases

直到今年，已有數千起病例

that have been diagnosed in the US were contracted elsewhere.

在美國被確診出來， 但卻是在別處受到感染的。

But as of this summer, it's being transmitted locally in Miami.

但今年夏天在邁阿密當地 已出現本土傳播病例，

It's here.

就在這裡。

So what do we do about it?

所以我們該怎麼辦?

Well, preventing infection

避免感染，

is either about protecting people or about eliminating the mosquitoes.

不是保護民眾就是消滅蚊蟲。

Let's focus on people first.

我們先從人的面向來看。

You can get vaccinated.

你可以注射疫苗。

You can not travel to Zika areas.

不要去有茲卡疫情的地區。

Or you can cover up and apply insect repellent.

或是全身包起來噴防蚊液。

Getting vaccinated is not an option, because there isn't a vaccine yet

注射疫苗不在考量的範圍內， 因為根本就還沒有疫苗。

and there probably won't be for a couple of years.

且接下來幾年也許都不會有。

Staying home isn't a foolproof protection either

一直待在家裡也不是個方法。

because we now know that it can be sexually transmitted.

因為我們現在知道 它也可以透過性交傳染。

Covering up and applying insect repellent does work ...

包得緊緊地跟噴防蚊液是有用的，

until you forget.

除非你忘了。

(Laughter)

(笑聲)

So that leaves the mosquitoes, and here's how we control them now:

那就從蚊子下手吧， 我們控制的方法就是：

spraying insecticides.

噴灑殺蟲劑。

The protective gear is necessary because these are toxic chemicals

防護員一定要穿防護衣， 因為那是有毒的化學物質，

that kill people as well as bugs.

它不只殺蟲，也可以殺人。

Although it does take quite a lot more to kill a person than to kill a bug.

只是殺人的劑量比殺蟲來的高很多。

These are pictures from Brazil and Nicaragua.

這是在巴西和尼加拉瓜的照片。

But it looks the same in Miami, Florida.

但看起來和佛羅里達的邁阿密一樣。

And we of course can spray insecticides from planes.

當然我們也可以用飛機噴灑殺蟲劑。

Last summer, mosquito control officials in Dorchester County, South Carolina,

去年夏天，

南卡州多徹斯特郡的蚊蟲控制人員，

authorized spraying of Naled, an insecticide,

被授權准許噴灑一種 叫乃力松的殺蟲劑。

early one morning, as recommended by the manufacturer.

製造商建議要在早上噴藥。

Later that day, a beekeeper told reporters

當天傍晚，有養蜂人跟記者說，

that her bee yard looked like it had been nuked.

她的養蜂場看起來 像被轟炸過一樣。

Oops.

哇……

Bees are the good guys.

蜜蜂是好的昆蟲。

The citizens of Florida protested, but spraying continued.

佛羅里達居民發起抗議， 當局卻依然故我。

Unfortunately, so did the increase in the number of Zika fever cases.

不幸的是，茲卡病例仍在增加。

That's because insecticides aren't very effective.

那是因為殺蟲劑不夠有效。

So are there any approaches that are perhaps more effective than spraying

那有什麼方法 是比噴灑殺蟲劑還有效，

but with less downsides than toxic chemicals?

但副作用比有毒的化學藥劑小？

I'm a huge fan of biological controls,

我非常推崇生物控制這個方式。

and I share that view with Rachel Carson, author of "Silent Spring,"

我向瑞秋卡森分享我的想法， 她是《寂靜春天》的作者。

the book that is credited with starting the environmental movement.

這本書促使了環境保護運動的抬頭。

In this book she tells the story, as an example,

她在書中以故事為例，

of how a very nasty insect pest of livestock

說明了一種非常討人厭的牲畜害蟲

was eliminated in the last century.

是如何在上世紀滅絕的。

No one knows that extraordinary story today.

現在沒人知道這個驚人的故事。

So Jack Block and I, when we were writing an editorial

所以當時我和傑克布拉克就一起

藉由重述這個故事的方式， 寫了篇有關蚊子問題的社論，

about the mosquito problem today, retold that story.

And in capsule form, it's that pupae -- that's the immature form of the insect --

簡而言之，

在昆蟲尚未成蟲仍是蛹的時後，

were irradiated until they were sterile, grown to adulthood

就用放射線照射， 使他們無繁殖能力，

牠們長大成蟲後， 用飛機將牠們釋放到西南部、

and then released from planes all over the Southwest,

the Southeast and down into Mexico and into Central America

東南部、往下到墨西哥跟中美洲，

literally by the hundreds of millions from little airplanes,

直接從小飛機放飛幾億隻的蚊子，

eventually eliminating that terrible insect pest

最後將這糟糕的害蟲

for most of the Western Hemisphere.

從西半球消失。

Our real purpose in writing this editorial

我們寫這篇社論的用意，

was to introduce readers to how we can do that today --

是要告訴讀者 我們現在可以怎麼做──

not with radiation but with our knowledge of genetics.

不是靠放射線的方式， 而是靠我們對遺傳學的知識。

Let me explain.

讓我解釋一下。

This is the bad guy: Aedes aegypti.

這個壞蛋 : 白線斑蚊。

It's the most common insect vector of diseases,

這個昆蟲是最常見的疾病帶原者，

not just Zika but dengue, Chikungunya, West Nile virus

不只是茲卡，還有登革熱、 屈公熱、西尼羅病毒

and that ancient plague, yellow fever.

和那個古老的瘟疫黃熱病。

It's an urban mosquito,

牠是一種都市型蚊子，

and it's the female that does the dirty work.

而且只有母蚊子會咬人。

She bites to get a blood meal to feed her offspring.

她咬人是為了吸血來餵食後代。

Males don't bite; they don't even have the mouth parts to bite.

公蚊子不會叮人， 牠們甚至沒有叮人的器官。

A little British company called Oxitec genetically modified that mosquito

一間名為 Oxitec 的英國生技小公司 修改了蚊子的基因，

so that when it mates with a wild female, its eggs don't develop to adulthood.

讓公蚊和野生母蚊子生下的卵 無法順利成長至成年。

Let me show you.

我秀給大家看。

This is the normal reproductive cycle.

這是正常的傳宗接代週期，

Oxitec designed the mosquito so that when the male mates with the wild female

Oxitec 則是讓公蚊子和 野生母蚊子交配後

the eggs don't develop.

產下的卵無法成長。

Sounds impossible?

聽起來很不可思議？

Well let me show you just diagrammatically how they do it.

讓我用圖解的方式告訴各位 他們是怎麼辦到的。

Now this represents the nucleus of a mosquito cell,

這個代表蚊子細胞裡的細胞核，

and that tangle in the middle represents its genome,

中間一坨一坨的代表牠的基因組，

the sum total of its genes.

也就是所有的基因。

Scientists added a single gene

科學家插入了一個基因，

that codes for a protein represented by this orange ball

圖中橘色球代表被編碼過的蛋白質，

that feeds back on itself to keep cranking out more of that protein.

這蛋白質會被回植到細胞裡，

然後開始持續大量 增生出同樣的蛋白質。

The extra copies, however, go and gum up the mosquitoes' genes,

然而，多餘的蛋白質 會把蚊子的基因黏合在一起，

killing the organism.

並摧毀有機體。

To keep it alive in the laboratory they use a compound called tetracycline.

為了讓公蚊在實驗室存活， 他們使用了一種合成物稱作四環素。

Tetracycline shuts off that gene and allows normal development.

四環素會關掉那個基因， 並且讓公蚊正常成長。

They added another little wrinkle so that they could study what happens.

他們也運用了一個小技巧， 來研究公蚊的變化。

And that is they added a gene that makes the insect glow under UV light

他們插入了另一個基因， 讓昆蟲在紫外線燈底下成長，

so that when they released it they could follow exactly how far it went

在將來釋放公蚊後， 好跟蹤牠們飛了多遠、

how long it lived and all of the kinds of data

活了多久，

還有將來方便各種研究的資料。

for a good scientific study.

Now this is the pupal stage, and at this stage

這是蛹的階段，而在這個階段，

the females are larger than the males.

雌性會比雄性來得大。

That allows them to sort them into the males and the females

所以他們能將雄性和雌性區分開來，

and they allow only the males to grow to adulthood.

而且他們只讓公蚊長大至成蚊。

And let me remind you that males don't bite.

我再次提醒各位，公蚊不會咬人。

From there it's pretty simple.

這樣就單純多了。

They take beakers full of male mosquitoes,

他們把裝滿蚊子的燒杯

load them into milk cartons, and drive around the city,

裝進牛奶箱子，然後開車繞市區，

releasing them guided by GPS.

並且根據衛星定位將牠們釋放。

Here's the mayor of a city releasing the first batch

這位市長釋放了第一批蚊子，

of what they call the "friendly Aedes."

他們稱這些蚊子為 「友善的埃及伊蚊」。

Now I wish I could tell you this is an American city, but it's not.

跟各位說，我希望 這是在美國的城市，但並不是。

It's Piracicaba, Brazil.

這是在巴西的皮拉西卡巴。

The amazing thing is that in just a year

最驚奇的是，僅僅才一年的時間，

it brought down the cases of dengue by 91 percent.

登革熱的案例下降了 91% 。

That's better than any insecticide spraying can do.

比噴灑任何殺蟲劑 所得到的成果好太多了。

So why aren't we using this remarkable biological control in the US?

所以我們為何不在美國 使用這個卓越的生物防治方法呢？

That's because it's a GMO: a genetically modified organism.

那是因為牠是GMO： 基因改造生物。

Notice the subtitle here says if the FDA would let them

注意看一下副標題寫的， 如果美國食藥管理局同意，

they could do the same thing here, when Zika arrives.

當茲卡病毒爆發時， 他們可以在這裡做同樣的事。

And of course it has arrived.

當然茲卡的確來了。

So now I have to tell you the short form

所以現在我用簡短的方式， 來向各位說明

of the long, torturous story of GM regulation in the US

這個在美國 又臭又長的基因改造規範。

In the US, there are three agencies that regulate genetically modified organisms:

在美國，有三個機構 在管理基因改造的生物：

the FDA, the Food and Drug Administration,

FDA ，食品藥物管理局，

the EPA, the Environmental Protection Agency,

EPA，國家環境保護局，

and the USDA, US Department of Agriculture.

以及 USDA，美國農業部。

Took these folks two years to decide that it would be the FDA

這些單位花了兩年的時間 才決定由食品藥物管理局

that would regulate the genetically modified mosquito.

來規範管理基因改造蚊子，

And they would do it as a new animal drug, if that makes any sense.

如果有效，他們會將它 看成是一種新的動物藥品，

Took them another five years going back and forth and back and forth

然後又花了五年的時間來來回回，

to convince the FDA that this would not harm people,

說服食品藥物管理局 這不會對人類有害，

and it would not harm the environment.

也不會對環境有害。

They finally gave them, this summer, permission to run a little test

在今年夏天，他們終於同意

在佛羅里達群島做一個小小的測試，

in the Florida Keys,

where they had been invited years earlier when they Keys had an outbreak of dengue.

在幾年前登革熱爆發的時候， 他們就被邀請這麼做了。

Would that it were that easy.

要是這麼簡單就好了。

When the local residents heard

當地的居民一聽到，

that there would be genetically modified mosquitoes tested in their community

會有基因改造的蚊子被釋放到 他們的社區試驗時，

some of them began to organize protests.

部分居民就開始組織抗議行動。

They even organized a petition on the internet with this cuddly logo,

他們甚至在網上發送 有這個可愛標誌的請願書，

which eventually accumulated some 160,000 signatures

最終獲得了 16 萬人的簽名聯署。

And they demanded a referendum

他們要求公投，

which will be conducted in just a couple of weeks

並且會在幾個禮拜內就舉行，

about whether the trials would be permitted at all.

決定這個試驗是否應該被批准。

Well it's Miami that really needs these better ways of controlling insects.

但其實邁阿密才是真正需要 這個方法來控制蚊蟲的地方。

And there the attitudes are changing.

那邊的態度正在改變。

In fact, very recently a bipartisan group of more than 60 legislators

事實上，最近一個包含 60 多個立法委員的兩黨組織

wrote to HHS Secretary Sylvia Burwell

寫信給美國公衛部部長 希爾維雅布爾維爾，

asking that she, at the Federal level, expedite access for Florida

要求她在聯邦高層 加速完成佛羅里達

to this new technology.

對這項科技的請求。

So the bottom line is this:

所以結論是：

biological control of harmful insects

利用生物控制來控制害蟲，

can be both more effective and very much more environmentally friendly

遠比使用有毒的化學藥物殺蟲劑

than using insecticides, which are toxic chemicals.

來得有效，且對環境也比較友善。

That was true in Rachel Carson's time; it's true today.

這在瑞秋卡森的時代是正確的， 在我們的時代也是。

What's different is that we have enormously more information

不一樣的是，我們比當時的人

擁有更多基因學方面的知識，

about genetics than we had then,

and therefore more ability to use that information

因此我們擁有更多的能力 來運用那這些資訊，

to affect these biological controls.

來影響控制這些生物。

And I hope that what I've done is aroused your curiosity enough

我希望我有引起各位的好奇心，

to start your own inquiry -- not into just GM mosquitoes

讓各位開始進行研究── 不只是基因改造蚊子，

but to the other genetically modified organisms that are so controversial today.

還有其它當今仍備受爭議的 基因改造生物。

I think if you do that, and you dig down through all of the misinformation,

我想如果你開始研究， 並往下挖掘所有的誤導資訊，

and the marketing

以及有機食品產業和

on the part of the organic food industry and the Greenpeaces

綠色和平組織的市場手段，

and find the science, the accurate science,

去尋找科學、正確的科學，

you'll be surprised and pleased.

那你會感到非常震驚且高興的。

Thank you.

謝謝。

(Applause)

（掌聲）