This tiny particle could roam your body to find tumors | Sangeeta Bhatia

In the space that used to house one transistor,

we can now fit one billion.

That made it so that a computer the size of an entire room

now fits in your pocket.

You might say the future is small.

As an engineer,

I'm inspired by this miniaturization revolution in computers.

As a physician,

I wonder whether we could use it to reduce the number of lives lost

due to one of the fastest-growing diseases on Earth:

cancer.

Now when I say that,

what most people hear me say is that we're working on curing cancer.

And we are.

But it turns out

that there's an incredible opportunity to save lives

through the early detection and prevention of cancer.

Worldwide, over two-thirds of deaths due to cancer are fully preventable

using methods that we already have in hand today.

Things like vaccination, timely screening

and of course, stopping smoking.

But even with the best tools and technologies that we have today,

some tumors can't be detected

until 10 years after they've started growing,

when they are 50 million cancer cells strong.

What if we had better technologies

to detect some of these more deadly cancers sooner,

when they could be removed,

when they were just getting started?

Let me tell you about how miniaturization might get us there.

This is a microscope in a typical lab

that a pathologist would use for looking at a tissue specimen,

like a biopsy or a pap smear.

This $7,000 microscope

would be used by somebody with years of specialized training

to spot cancer cells.

This is an image from a colleague of mine at Rice University,

Rebecca Richards-Kortum.

What she and her team have done is miniaturize that whole microscope

into this $10 part,

and it fits on the end of an optical fiber.

Now what that means is instead of taking a sample from a patient

and sending it to the microscope,

you can bring the microscope to the patient.

And then, instead of requiring a specialist to look at the images,

you can train the computer to score normal versus cancerous cells.

Now this is important,

because what they found working in rural communities,

is that even when they have a mobile screening van

that can go out into the community and perform exams

and collect samples

and send them to the central hospital for analysis,

that days later,

women get a call with an abnormal test result

and they're asked to come in.

Fully half of them don't turn up because they can't afford the trip.

With the integrated microscope and computer analysis,

Rebecca and her colleagues have been able to create a van

that has both a diagnostic setup and a treatment setup.

And what that means is that they can do a diagnosis

and perform therapy on the spot,

so no one is lost to follow up.

That's just one example of how miniaturization can save lives.

Now as engineers,

we think of this as straight-up miniaturization.

You took a big thing and you made it little.

But what I told you before about computers

was that they transformed our lives

when they became small enough for us to take them everywhere.

So what is the transformational equivalent like that in medicine?

Well, what if you had a detector

that was so small that it could circulate in your body,

find the tumor all by itself

and send a signal to the outside world?

It sounds a little bit like science fiction.

But actually, nanotechnology allows us to do just that.

Nanotechnology allows us to shrink the parts that make up the detector

from the width of a human hair,

which is 100 microns,

to a thousand times smaller,

which is 100 nanometers.

And that has profound implications.

It turns out that materials actually change their properties

at the nanoscale.

You take a common material like gold,

and you grind it into dust, into gold nanoparticles,

and it changes from looking gold to looking red.

If you take a more exotic material like cadmium selenide --

forms a big, black crystal --

if you make nanocrystals out of this material

and you put it in a liquid,

and you shine light on it,

they glow.

And they glow blue, green, yellow, orange, red,

depending only on their size.

It's wild! Can you imagine an object like that in the macro world?

It would be like all the denim jeans in your closet are all made of cotton,

but they are different colors depending only on their size.

(Laughter)

So as a physician,

what's just as interesting to me

is that it's not just the color of materials

that changes at the nanoscale;

the way they travel in your body also changes.

And this is the kind of observation that we're going to use

to make a better cancer detector.

So let me show you what I mean.

This is a blood vessel in the body.

Surrounding the blood vessel is a tumor.

We're going to inject nanoparticles into the blood vessel

and watch how they travel from the bloodstream into the tumor.

Now it turns out that the blood vessels of many tumors are leaky,

and so nanoparticles can leak out from the bloodstream into the tumor.

Whether they leak out depends on their size.

So in this image,

the smaller, hundred-nanometer, blue nanoparticles are leaking out,

and the larger, 500-nanometer, red nanoparticles

are stuck in the bloodstream.

So that means as an engineer,

depending on how big or small I make a material,

I can change where it goes in your body.

In my lab, we recently made a cancer nanodetector

that is so small that it could travel into the body and look for tumors.

We designed it to listen for tumor invasion:

the orchestra of chemical signals that tumors need to make to spread.

For a tumor to break out of the tissue that it's born in,

it has to make chemicals called enzymes

to chew through the scaffolding of tissues.

We designed these nanoparticles to be activated by these enzymes.

One enzyme can activate a thousand of these chemical reactions in an hour.

Now in engineering, we call that one-to-a-thousand ratio

a form of amplification,

and it makes something ultrasensitive.

So we've made an ultrasensitive cancer detector.

OK, but how do I get this activated signal to the outside world,

where I can act on it?

For this, we're going to use one more piece of nanoscale biology,

and that has to do with the kidney.

The kidney is a filter.

Its job is to filter out the blood and put waste into the urine.

It turns out that what the kidney filters

is also dependent on size.

So in this image, what you can see

is that everything smaller than five nanometers

is going from the blood, through the kidney, into the urine,

and everything else that's bigger is retained.

OK, so if I make a 100-nanometer cancer detector,

I inject it in the bloodstream,

it can leak into the tumor where it's activated by tumor enzymes

to release a small signal

that is small enough to be filtered out of the kidney

and put into the urine,

I have a signal in the outside world that I can detect.

OK, but there's one more problem.

This is a tiny little signal,

so how do I detect it?

Well, the signal is just a molecule.

They're molecules that we designed as engineers.

They're completely synthetic, and we can design them

so they are compatible with our tool of choice.

If we want to use a really sensitive, fancy instrument

called a mass spectrometer,

then we make a molecule with a unique mass.

Or maybe we want make something that's more inexpensive and portable.

Then we make molecules that we can trap on paper,

like a pregnancy test.

In fact, there's a whole world of paper tests

that are becoming available in a field called paper diagnostics.

Alright, where are we going with this?

What I'm going to tell you next,

as a lifelong researcher,

represents a dream of mine.

I can't say that's it's a promise;

it's a dream.

But I think we all have to have dreams to keep us pushing forward,

even -- and maybe especially -- cancer researchers.

I'm going to tell you what I hope will happen with my technology,

that my team and I will put our hearts and souls

into making a reality.

OK, here goes.

I dream that one day,

instead of going into an expensive screening facility

to get a colonoscopy,

or a mammogram,

or a pap smear,

that you could get a shot,

wait an hour,

and do a urine test on a paper strip.

I imagine that this could even happen

without the need for steady electricity,

or a medical professional in the room.

Maybe they could be far away

and connected only by the image on a smartphone.

Now I know this sounds like a dream,

but in the lab we already have this working in mice,

where it works better than existing methods

for the detection of lung, colon and ovarian cancer.

And I hope that what this means

is that one day we can detect tumors in patients

sooner than 10 years after they've started growing,

in all walks of life,

all around the globe,

and that this would lead to earlier treatments,

and that we could save more lives than we can today,

with early detection.

Thank you.

(Applause)