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00:00
Transcriber: Andrea McDonough
Reviewer: Bedirhan Cinar
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翻译人员: Miranda Dong
校对人员: Jenny Yang
00:14
I would like to introduce you
to my favorite parasite.
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我想介绍给你们我最喜欢的寄生虫
00:19
There are millions that I could choose from
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我有上百种可以选择
00:21
and this is it:
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然而我选择了它
00:22
it's called the jewel wasp.
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它就是扁头泥蜂(也叫宝石蜂)
00:24
You can find it
in parts of Africa and Asia.
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你可以在非洲和亚洲的部分地区找到它
00:27
It's a little under an inch long,
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不到1英寸长
00:28
and it is a beautiful looking parasite.
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而且是种很美丽的寄生虫
00:30
Now, you may be saying to yourself,
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现在,你可能会说
00:32
"This is not a parasite.
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“这不是寄生虫吧”
00:34
It's not a tapeworm,
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它不是绦虫
00:35
it's not a virus,
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00:35
how could a wasp be a parasite?"
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不是病毒
蜂子怎能能是寄生虫呢?
00:38
You are probably thinking
about regular wasps,
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你可能想到的是平常的黄蜂
00:40
you know, the ones that build
paper nests as their house.
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就是,住在自己纸筑的巢里的那种
00:45
Well, the thing is that the jewel wasp
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但对于扁头泥蜂
00:48
makes its house inside
a living cockroach.
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它住在活的蟑螂身体里
00:54
Here's how it happens.
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让我告诉你们这是怎么回事
00:57
A jewel wasp is flying around,
looking for a cockroach.
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一只扁头泥蜂飞来飞去,寻找蟑螂
01:00
When it sees one, it lands
and bites on its wing.
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当它找到了,就会落下并咬蟑螂的翅膀
01:03
So, I'll be the cockroach.
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现在,我是那只蟑螂
01:04
Be-wha! Bewha!
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哎呦,我去!
01:06
And the cockroach starts shaking it off,
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蟑螂想把它甩下来
01:08
"Get away from me!"
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“离我远点!”
01:10
The wasp very quickly starts
stinging the cockroach.
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扁头泥蜂会很快地叮咬蟑螂
01:14
All of a sudden, the cockroach can't move,
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一瞬之间,蟑螂就动不了了
01:17
for about a minute.
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过了约一分钟
01:18
And then it recovers
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它苏醒过来
01:21
and stands up.
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站起来
01:22
It could run away now,
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它现在可以逃跑了
01:24
but it doesn't.
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但它并没有
01:26
It just doesn't want to.
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它不愿意逃跑了
01:28
It just stays there.
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只是待在那儿
01:30
It's become a zombie slave.
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成为了一具僵尸奴隶
01:35
Again, I'm not making this up.
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我没有逗你们玩
01:37
The wasp goes off,
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扁头泥蜂飞走了
01:38
it walks away and finds a hole
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飞走并找了一个洞
01:41
and digs it out, makes it into a burrow.
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挖掘它让它可以容身
01:44
It walks back.
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然后返回去
01:45
This can take up to half an hour.
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这期间有半个小时
01:48
The cockroach is still there.
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蟑螂还在哪儿
01:51
What do we do now?
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现在要干嘛?
01:53
The wasps grabs onto one of the antenna,
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扁头泥蜂抓住蟑螂的一根触角
01:56
bites down on it,
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咬住
01:58
of the cockroach,
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蟑螂的触角
01:59
and pulls the cockroach.
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然后拖着蟑螂
02:01
And the cockroach says, "Alright,"
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蟑螂说,“好吧”
02:04
and walks like a dog on a leash.
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就像被牵住的狗
02:07
The wasp takes it
all the way down into the burrow.
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扁头泥蜂把蟑螂一路拖回那个洞
02:11
The cockroach says, "Nice place."
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蟑螂说,“是个好地方”
02:14
The wasp takes care of some business
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扁头泥蜂仔细地做了点什么
02:16
and then goes and leaves the burrow
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然后离开了洞穴
02:17
and seals it shut,
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封闭洞口
02:19
leaving the cockroach entombed
in darkness, still alive.
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留下蟑螂被埋在洞中,还是活的
02:23
The cockroach says, "Alright,
I'll stay here if you want."
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蟑螂说,“好吧,如果你让我待在这我就待吧”
02:27
Now, I mentioned that
the cockroach took care,
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记得我刚刚提到,蟑螂做了点
02:29
ah, the wasp took care
of a little business
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啊不,扁头泥蜂在离开之前
02:32
before it left the burrow.
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做了点什么
02:34
The business was laying an egg
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那就是产卵
02:37
on the underside of the cockroach.
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在蟑螂胸部下方产卵
02:39
The egg hatches.
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卵孵化后
02:40
Out comes a wasp larva.
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扁头泥蜂幼虫就出来了
02:42
It looks kind of like
a maggot with big, nasty jaws.
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它看上去像有恶心大嘴的蛆
02:45
It chews a hole into the cockroach
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在蟑螂身上咬了个洞
02:49
and starts to feed from the outside.
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从外面开始吃蟑螂的身体
02:51
It gets bigger,
like you can see over here.
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当它长大了,就像图里右边的
02:55
And then when it gets big enough,
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当它长得足够大了
02:56
it decides to crawl into the hole,
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它就决定爬到洞里
03:00
into the cockroach.
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爬到蟑螂身体里
03:02
So now it's inside
the still-living cockroach
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所以现在幼虫住在了仍然活着的蟑螂身体里
03:05
and the cockroach doesn't mind much.
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而蟑螂并不在意
03:09
This goes on for about a month.
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有大约一个月的时间
03:11
The larva grows and grows and grows,
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幼虫持续成长,成长,再成长
03:14
then makes a pupa,
kind of like a cocoon.
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然后化蛹,类似于做茧
03:16
Inside there it grows eyes,
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在里面长出眼睛
03:18
it grows wings,
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翅膀
03:19
it grows legs,
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腿
03:21
the cockroach is still alive,
still waiting.
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这段时间蟑螂仍是活的,仍在等待
03:24
Finally the wasp is ready to leave,
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最终泥蜂准备好离开了
03:27
and that's when the cockroach finally dies
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也就是蟑螂最终死去的时候
03:30
because the fullly-formed adult wasp
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因为这只完全态的成年泥蜂
03:33
crawls out of the cockroach's dying body.
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要爬出快死蟑螂的身体
03:38
The wasp shakes itself off,
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泥蜂抖动它的身体
03:40
climbs out of the burrow,
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爬出洞穴
03:42
goes and finds another wasp to mate with
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离开并寻找另一只进行交配
03:44
to start this whole, crazy cycle again.
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然后开始疯狂的新一轮循环
03:47
So, this is not science fiction,
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是,这不是科幻故事
03:50
this happens every day,
all over the world.
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它每天在世界各地发生着
03:54
And scientists are
totally fascinated by this.
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而科学家们完全为其着迷
03:58
They're just starting to figure out
how all this happens.
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他们刚开始研究这是怎么做到的
04:01
And, when you really start
to look at the science of it,
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当你认真开始关注其中的科学时
04:04
you start to kind of respect
this very creepy wasp.
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你会开始敬佩这种令人毛骨悚然的泥蜂
04:08
You see, the thing is that
when it attacks the cockroach,
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要知道,当它攻击蟑螂时
04:12
it's not just stinging wildly,
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并不是随便叮咬
04:13
it delivers two precise stings.
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它叮咬两个特定的地方
04:18
It knows this cockroach's nervous system
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它熟悉蟑螂的神经系统
04:21
like you know the back of your hand.
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就像你熟悉你的手背
04:23
The first sting goes to that spot there,
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第一处叮咬的是圆点的位置
04:26
called the "walking rhythm generators,"
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叫做运动规律发生器
04:28
and, as you can guess,
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从名字你可以猜到
04:29
those are the neurons that send signals
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这些神经细胞发出的信号
04:30
to the legs to move.
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控制腿部运动
04:33
It blocks the channels
that the neurons use
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叮咬阻止了神经通道
04:36
to send these signals.
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04:36
So the cockroach wants to go,
it wants to run away,
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向腿部传递信号
所以蟑螂实际上想逃的,很想逃跑
04:39
but it can't because
it can't move its legs.
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但是它的腿已经无法移动了
04:42
And that lasted for about a minute.
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然后这样持续一分钟
04:45
This is really sophisticated pharmacology.
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这是很复杂的药理学
04:49
We actually use the same method,
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实际上我们也有类似的方法
04:51
a drug called Ivermectin,
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一种叫做伊维菌素的药
04:53
to cure river blindness,
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来治疗蟠尾丝虫症(河川盲)
04:54
which is caused by a parasitic worm
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它是由于一种寄生蠕虫
04:55
that gets into your eye.
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进到了你的眼睛里
04:57
If you take Ivermectin,
you paralyze the worm
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如果你使用伊维菌素,你就使用相同的策略
05:00
using the same strategy.
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让蠕虫瘫痪了
05:03
Now, we discovered this in the 1970s,
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我们在1970年代发现这个治疗方法
05:05
the wasp has been doing this for millions of years.
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泥蜂却已经这样做了上百万年
05:09
Then comes the second sting.
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然后它第二次叮咬蟑螂
05:11
Now the second sting actually hits two places along the way.
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实际上第二次叮咬,沿途有两个地方
05:14
And to try to imagine how this can happen,
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试着想象一下
05:18
I want you to picture yourself with a friend
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想象一个画面,你和你的朋友
05:22
who's got a very long, very, very scary looking needle.
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他有一根非常非常吓人的长针
05:25
And your friend,
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你的朋友
05:26
or at least you thought he was your friend,
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或者至少你认为他是朋友
05:28
sticks it in your neck,
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把针戳近了你的脖子
05:31
goes into your skull,
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戳到你的脑壳里
05:33
stops off at one part of your brain
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戳到一部分脑子的时候停了下来
05:35
and injects some drugs,
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注射了一些药
05:38
then keeps going in your brain
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然后继续往里戳
05:40
and injects some more.
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继续注射更多的药
05:43
These are two particular spots,
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这里有两个特别的点
05:45
marked here, "SEG",
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标注为“SEG”
05:46
and you can see the tip of it in the brain, marked "Br".
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你能看到图里蟑螂脑子末梢的标记,“Br”
05:50
Now, we can do this, but it's really hard for us.
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现在我们也可以这样做,不过挺难的
05:55
It's called stereotactic drug delivery.
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它叫做立体定位药物递送
05:57
You have to put a patient in a big metal frame
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你必须把病人放在一个大型金属框架里
06:00
to hold them still,
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保持他们不能动
06:01
you need CAT Scans to know where you're going,
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你需要CT扫描来监看进行到哪儿了
06:03
so you look at the picture and say,
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所以你看着图片,然后说
06:05
"Are we going the right way?"
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“我们进行的对吗?”
06:07
The jewel wasp has sensors on its stinger
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扁头泥蜂在自己的蛰刺上有传感器
06:10
and scientists think that it can actually feel its way
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科学家认为它自己可以感知行进路线
06:14
through the cockroach's brain until it gets
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直达蟑螂的大脑
06:17
to the exact, right place,
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精确到达正确位置
06:19
and then penetrates an individual neuron
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刺入一个特定的神经元
06:22
and then delivers the goods.
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然后把东西注入进去
06:25
So, this is quite amazing stuff,
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所以这是很惊人的本事
06:29
and what seems to happen then
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接下来发生的
06:31
is that the wasp is taking away the control
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就是泥蜂取得了控制权
06:36
that the cockroach has over its own body.
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蟑螂的身体不受控制
06:39
It's taking away the cockroach's free will.
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自由意志被泥蜂剥夺了
06:42
We didn't really appreciate that cockroaches
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我们在泥蜂这么做之前
06:43
have free will until this wasp showed us.
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都没有认识到蟑螂还有自由意志
06:46
And, we have no idea how it's doing this,
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此外,我们还有很多不了解的
06:50
we don't know yet what the venom has in it
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我们还不知道这是什么毒液
06:52
and we don't know which circuits
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我们不知道它攻击的是蟑螂脑部
06:53
it's hitting in the cockroach's brain,
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哪一部分回路
06:56
and I think that's why this is,
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这就是我为什么
06:58
most of all, my favorite parasite
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在所有寄生虫当中,最喜欢扁头泥蜂
07:00
because we have so much left to learn from it.
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因为我们还有很多要向它学习的地方
07:03
Thank you very much.
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非常感谢各位的聆听
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