CRISPR's Next Advance Is Bigger Than You Think | Jennifer Doudna | TED

The essence of being human is that we solve problems.

And when we're faced with enormous problems

like disease and climate change,

we need to solve them by collaboration.

I'm excited to tell you about a new kind of collaboration

that will absolutely create solutions to these big problems.

It's a collaboration that's unexpected

because it's between humans

and the tiniest organisms that populate our planet:

the bacteria and other microbes that live in, on and around us.

Bacteria may be small and unseen,

but they often have inspired transformative innovations,

including the one that has become the cornerstone of my own research.

Over the past decade, I've been at the forefront

of developing a revolutionary technology called CRISPR

that has come from the study of how bacteria fight viral infection.

CRISPR is amazing because it allows us

to precisely edit the DNA in living organisms,

including in people and plants.

With CRISPR, we can change, remove or replace the genes

that govern the function of cells.

This means that we now have the ability to use CRISPR like a word processor

to find, cut and paste text.

CRISPR, amazingly, has already cured people of devastating disorders

like sickle cell disease,

and it's created rice plants

that are resistant to both diseases and drought.

Incredible, right?

But the next world-changing advance with CRISPR

will actually come from using it in a way

that will allow us to go to the next level

by editing genes beyond just in individual organisms.

We now have the ability to use CRISPR

to edit entire populations of tiny microbes,

called microbiomes,

that live in and on our bodies.

For decades, scientists studied bacteria one organism at a time,

as if each type of bacteria behaved independently.

But we now know that bacterial behaviors,

both good and bad,

result from their interactions within complex microbiomes.

In humans, dysfunctional gut microbiomes

are associated with diseases as diverse as Alzheimer's and asthma.

And in farm animals, microbiomes produce methane,

a powerful contributor to climate change.

But when they're healthy,

both human and animal microbiomes can actually prevent disease

and reduce methane emissions.

So to harness these benefits,

we need a way to precisely and reproducibly control

these microbial communities.

So why have microbiomes been difficult to control in the past?

It turns out that microbiomes are very complex,

and they're difficult to manipulate.

Antibiotics affect the entire microbiome

and their overuse can lead to drug resistance.

Diet and probiotics are nonspecific

and they're often ineffective.

Fecal transplants face various challenges to both effectiveness and acceptance.

(Laughter)

But with CRISPR, we have a tool that works like a scalpel.

It allows us to target a particular gene in a particular kind of cell.

With CRISPR, we can change one kind of bacterium

without affecting all the others.

Another challenge is that less than one percent of the world’s microbial species

have been grown and studied in the lab.

Fortunately, we can now access the other 99 percent

due to the pioneering research of my colleague, Jill Banfield,

and her breakthrough technology,

metagenomics,

which is a tool that allows us to figure out

what species are present

and what they're doing in a microbial community.

Metagenomics creates a detailed blueprint of a complex microbiome,

and that means that we can use it

to figure out how to use gene editing tools

in the right gene, in the right organism.

You might be wondering how we can take this new knowledge

and harness it to solve real world problems.

Well, we're bringing together these two breakthrough technologies,

metagenomics and CRISPR,

to create a brand new field of science called precision microbiome editing.

This will allow us to discover links between dysfunctional microbiomes

and disease or greenhouse gas emissions.

We can develop modified and improved microbiome editors

and show that they're safe and effective.

And we can then begin to deploy these optimized solutions

to create the kinds of solutions that will be transformative in the future.

So how does this affect our health and the health of our planet?

We know the poorest countries and people are the most affected by climate change,

and it's a problem created by the wealthiest people.

And methane is a big part of the problem.

It's been a major contributor to rising global temperatures

since preindustrial times.

Specific microbiome compositions in livestock

can actually reduce methane emissions by up to 80 percent.

But doing that today currently requires daily interventions at enormous expense,

and it just doesn't scale.

But with precision microbiome editing,

we have an opportunity to modify a calf's microbiome at birth,

limiting that animal's impact on the climate for its entire lifetime.

And this is beneficial for farmers

because reduced methane production

means more efficient conversion of feed into food.

Importantly, these tools can be used in the future

to reduce methane emissions from other sources,

like landfills, wastewater and rice paddies.

Ultimately, microbiomes generate

up to two-thirds of all of the methane emissions globally.

So our technology could really move the needle

in our fight against climate change.

In human health,

asthma affects up to 300 million people around the world,

a number that grows by 50 percent each decade,

and it disproportionately affects lower-income children.

Our team has identified a promising link

between a molecule produced in the gut microbiome

and asthma development.

With precision microbiome editing,

we could offer a child at risk for asthma a noninvasive therapy

that would eliminate asthma-inducing molecules,

changing her life trajectory.

And what's really exciting

is that these same approaches in the future could help us treat

or even prevent human diseases

that are linked to the gut microbiome,

including obesity, diabetes and Alzheimer's.

I think it’s fascinating that we can now use CRISPR

to edit the same tiny organisms that gave us CRISPR.

In doing so, we’re collaborating with the ultimate partner: nature.

Together, we can use CRISPR-powered precision microbiome editing

to build a more resilient future for all of us.

Thank you very much.

(Applause)